Pro-Inflammatory Vδ1+ T-Cells Infiltrates Are Present In And Around The Hair Bulbs Of Non-Lesional And Lesional Alopecia Areata Hair Follicles

The study found that Vδ1+T-cells, a type of γδT-cells, were significantly increased in and around the hair bulbs of both lesional and non-lesional alopecia areata (AA) hair follicles, exhibiting a pro-inflammatory phenotype. This suggested their involvement in the early stages of AA pathobiology and highlighted their potential role in the innate immune response associated with AA. The findings proposed that targeting Vδ1+T-cells could be a promising therapeutic strategy for managing AA, emphasizing their previously overlooked significance in the condition.