research Targeting Pathogenic MICA-NKG2D Interactions by Statins: A Novel Adjunct Treatment Strategy for Alopecia Areata Management?
Statins may help treat alopecia areata by reducing harmful immune interactions.
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research Human αβ and γδ T Cells in Skin Immunity and Disease
Certain types of T cells are essential for healthy skin and play a role in skin diseases, but more research is needed to improve treatments.
research Butyrophilin-Like 2 to the Rescue: Controlling Autoaggressive Dermal Gamma Delta T Lymphocytes in Human Hair Follicles
The study investigates the role of Butyrophilin-like 2 (BTNL2) in regulating interactions between gamma/delta (GDT) T cells and hair follicles (HFs), particularly in the context of alopecia areata (AA). BTNL2 is primarily expressed in the outer root sheath keratinocytes of healthy human scalp HFs. The research found that stressed HFs exhibit significantly lower BTNL2 expression, which correlates with increased cytotoxic activity by VD1 GDT and CD8+ T cells, leading to HF damage characteristic of AA. This suggests that BTNL2 plays a crucial role in maintaining immune privilege in HFs and could be a potential target for future AA treatments.
research Relationship Between Serum 25-Hydroxyvitamin D Levels and Hormonal Status in Infertile Women: A Retrospective Study
Low vitamin D levels may affect ovulation and progesterone in infertile women.
research Development of PEGylated Liposomes
PEGylated liposomal doxorubicin improves cancer treatment effectiveness and reduces side effects like heart damage and hair loss.
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