A New Humanized Mouse Model For Alopecia Areata

    Amos Gilhar, Aviad Keren, Ralf Paus
    TLDR A new mouse model helps understand and find treatments for alopecia areata.
    The study developed a new humanized mouse model for alopecia areata (AA) to better understand its pathogenesis and identify effective treatments. This model involved transplanting healthy human scalp skin onto severe-combined immunodeficient mice, followed by injecting cultured peripheral blood mononuclear cells enriched for NKG2D+ and CD56+ cells. This method led to predictable hair loss with clinical features of AA, highlighting the role of these cells in the disease's pathogenesis and offering a promising tool for discovering new treatments.
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      in Treatment  2 upvotes 3 years ago
      A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

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