A New Humanized Mouse Model For Alopecia Areata

    December 2013 in “ Journal of Investigative Dermatology Symposium Proceedings ”
    Amos Gilhar, Aviad Keren, Ralf Paus
    TLDR A new mouse model helps understand and find treatments for alopecia areata.
    The study developed a new humanized mouse model for alopecia areata (AA) to better understand its pathogenesis and identify effective treatments. This model involved transplanting healthy human scalp skin onto severe-combined immunodeficient mice, followed by injecting cultured peripheral blood mononuclear cells enriched for NKG2D+ and CD56+ cells. This method led to predictable hair loss with clinical features of AA, highlighting the role of these cells in the disease's pathogenesis and offering a promising tool for discovering new treatments.
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      in Treatment  2 upvotes 3 years ago
      A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

      community mbp alopecia areata or vitamin deficiency

      in Chat 4 months ago
      A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

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      in Treatment  1 upvotes 1 year ago
      A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

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