Autoimmune Disease Induction in a Healthy Human Organ: A Humanized Mouse Model of Alopecia Areata

    October 2012 in “ Journal of Investigative Dermatology ”
    Amos Gilhar, Aviad Keren, Avner Shemer … Ralf Paus
    Studysummary This study developed an animal model that recreates alopecia areata by injecting healthy human skin grafts in immunocompromised mice with peripheral blood mononuclear cells enriched for NKG2D+ and CD56+ cells.
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    Research cited in this study 4

    1. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    2. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    3. Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack Journal of Investigative Dermatology · 2007
    4. Probing the Effects of Stress Mediators on the Human Hair Follicle American Journal of Pathology · 2007