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GlossaryNKG2D+ cells

immune cells with receptors targeting stressed or abnormal cells

NKG2D+ cells are immune cells that have a receptor called NKG2D on their surface. This receptor helps them recognize and destroy stressed or abnormal cells, such as those infected by viruses or transformed into cancer cells. These cells play a crucial role in the body's defense mechanisms, particularly in identifying and eliminating potential threats.

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research Mouse Models of Alopecia Areata: C3H/HeJ Mice Versus the Humanized AA Mouse Model

April 2019 in “Journal of Investigative Dermatology”

The humanized AA mouse model is better for testing new alopecia areata treatments.

research Autoimmune Disease Induction in a Healthy Human Organ: A Humanized Mouse Model of Alopecia Areata

75 citations , October 2012 in “Journal of Investigative Dermatology”

Alopecia areata can be triggered by specific immune cells without genetic or environmental factors.

research Latest Understanding and Treatment of Alopecia Areata

November 2016

New treatments for alopecia areata, like JAK inhibitors and immunomodulators, are promising.

research An Immune Regulatory CCT Repeat Containing Oligodeoxynucleotide Capable of Causing Hair Loss in Male Mice

January 2016 in “Human & Experimental Toxicology”

A specific DNA sequence caused hair loss in male mice by activating immune cells and increasing a certain immune signal.

research Mathematical Model for Alopecia Areata

6 citations , June 2015 in “Journal of theoretical biology”

The model showed that immune system guardians and the cytokine interferon-γ are key in alopecia areata progression.

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