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GlossaryNKG2D

receptor on immune cells that detects stressed or abnormal cells

NKG2D is a receptor found on the surface of certain immune cells, such as natural killer (NK) cells and some T cells. It plays a crucial role in the body's defense system by recognizing and binding to stress-induced molecules on infected or cancerous cells, thereby triggering an immune response to destroy these harmful cells.

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research Increased Blood Levels of NKG2D+CD4+ T Cells in Patients with Alopecia Areata

7 citations, December 2016 in “Journal of the American Academy of Dermatology”

NKG2D+CD4+ T cells are higher in alopecia areata patients and may be involved in the disease.

research Subset Analysis of NKG2D+ Cells in Peripheral Blood Mononuclear Cells

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

The study suggests that a specific type of immune cell, memory-like NK cells, may increase during active hair loss in Alopecia areata.

research Targeting Pathogenic MICA-NKG2D Interactions by Statins: A Novel Adjunct Treatment Strategy for Alopecia Areata Management?

November 2022 in “Journal of Investigative Dermatology”

Statins may help treat alopecia areata by reducing harmful immune interactions.

research Endoplasmic Reticulum Stress Upregulates NKG2D Ligands in the Hair Follicle

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Stress in hair follicle cells increases certain immune-related proteins, which might contribute to hair loss conditions.

research Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity

717 citations, June 2010 in “Nature”

Alopecia areata involves both innate and adaptive immunity, with specific genes linked to the disease.

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