Natural Killer Group 2 Type D (NKG2D) Gene Polymorphism in Systemic Lupus Erythematosus - Suez Canal Region, Egypt

The study examined the link between NKG2D gene polymorphism and systemic lupus erythematosus (SLE) in 50 Egyptian patients from the Suez Canal region, compared to 50 healthy controls. It found no significant association between the NKG2D SNP (rs2255336 G→A) and SLE susceptibility. However, there was a notable difference in clinical manifestations, such as inflammatory rash and hair loss, among different genotypes, with these symptoms being more common in GA & AA genotypes than in the GG genotype. This suggested that while the polymorphism did not affect SLE susceptibility, it might influence certain clinical features of the disease.