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    Glossary NKG2D

    receptor on immune cells that detects stressed or abnormal cells

    NKG2D is a receptor found on the surface of certain immune cells, such as natural killer (NK) cells and some T cells. It plays a crucial role in the body's defense system by recognizing and binding to stress-induced molecules on infected or cancerous cells, thereby triggering an immune response to destroy these harmful cells.

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    Research 30 of 482

    1. Increased blood levels of NKG2D+CD4+ T cells in patients with alopecia areata Journal of the American Academy of Dermatology · 2016 · 7 citations
    2. 058 Subset analysis of NKG2D+ cells in peripheral blood mononuclear cells 2023
    3. 026 Targeting pathogenic MICA-NKG2D interactions by statins: A novel adjunct treatment strategy for alopecia areata management? Journal of Investigative Dermatology · 2022
    4. Natural Killer Group 2 Type D (NKG2D) Gene Polymorphism in Systemic Lupus Erythematosus-Suez Canal Region - Egypt Suez Canal University Medical Journal · 2018
    5. 616 Endoplasmic reticulum stress upregulates NKG2D ligands in the hair follicle 2017
    6. Genome-wide association study in alopecia areata implicates both innate and adaptive immunity Nature · 2010 · 717 citations
    7. Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition Nature medicine · 2014 · 701 citations
    8. Alopecia Areata The New England Journal of Medicine · 2012 · 421 citations
    9. Alopecia areata: a review of disease pathogenesis 2018 · 191 citations
    10. Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies Autoimmunity reviews · 2016 · 82 citations
    11. The Role of Hair Follicle Immune Privilege Collapse in Alopecia Areata: Status and Perspectives Journal of Investigative Dermatology Symposium Proceedings · 2013 · 79 citations
    12. Autoimmune Disease Induction in a Healthy Human Organ: A Humanized Mouse Model of Alopecia Areata Journal of Investigative Dermatology · 2012 · 75 citations
    13. The PDE4 inhibitor, apremilast, suppresses experimentally induced alopecia areata in human skin in vivo Journal of Dermatological Science · 2014 · 52 citations
    14. iNKT cells ameliorate human autoimmunity: Lessons from alopecia areata Journal of autoimmunity · 2018 · 27 citations
    15. A New Humanized Mouse Model for Alopecia Areata Journal of Investigative Dermatology Symposium Proceedings · 2013 · 25 citations
    16. Treatment of alopecia areata: “What is new on the horizon?” Dermatologic therapy · 2011 · 25 citations
    17. Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 MKG2D Lymphocytes of Alopecia Areata Patients 2018 · 15 citations
    18. SIRT1 downregulation provokes immune-inflammatory responses in hair follicle outer root sheath cells and may contribute to development of alopecia areata Journal of Dermatological Science · 2023 · 13 citations
    19. Mathematical model for alopecia areata Journal of theoretical biology · 2015 · 6 citations
    20. Genes and Immune Response in Alopecia Areata: Review of the Alopecia Areata Research Summit First Day Proceedings Journal of Investigative Dermatology Symposium Proceedings · 2013 · 6 citations
    21. Pathophysiology of Alopecia Areata in the Pediatric Patient Pediatric Dermatology · 2025 · 5 citations
    22. Decreased CD19+CD24hiCD38hi Regulatory B Cells in Alopecia Areata Journal of Investigative Dermatology · 2024 · 5 citations
    23. From mechanisms to therapies: current advances breakthroughs in alopecia areata immunopathology Frontiers in Immunology · 2025 · 3 citations
    24. The investigation of selective sphingosine-1 phosphate receptor 1&4 modulator to treat alopecia areata mouse model The Journal of Immunology · 2023 · 2 citations
    25. The immunopathogenesis of Alopecia Areata Enlighten: Theses (The University of Glasgow) · 2020 · 2 citations
    26. 081 Simvastatin reduces autoimmune alopecia through direct action on T lymphocytes Journal of Investigative Dermatology · 2018 · 1 citations
    27. 051 γδ T cells as novel players in alopecia areata pathobiology: Vδ1 + T lymphocytes may recognize “stressed” hair follicle keratinocytes, leading to IFNγ-dependent hair follicle dystrophy and immune privilege collapse Journal of Investigative Dermatology · 2016 · 1 citations
    28. Advance Understanding and New Treatment of Alopecia Areata 2016 · 1 citations
    29. 396 Vδ1 + T-cells are stress-sentinels in human skin and are implicated in alopecia areata pathogenesis Journal of Investigative Dermatology · 2016 · 1 citations
    30. 315 Butyrophilin-like 2 (BTNL2) controls auto-aggressive dermal γδT lymphocytes that attack human hair follicles. Journal of Investigative Dermatology · 2025