Author Response: Involvement of ILC1-Like Innate Lymphocytes in Human Autoimmunity, Lessons from Alopecia Areata

September 2022

Rimma Laufer Britva, Aviad Keren, Marta Bertolini, Yehuda Ullmann, Ralf Paus, Amos Gilhar

alopecia areata ILC1-like innate lymphocytes NKG2D IFN-γ hair follicle immune privilege hair fiber dystrophy CD49a CD200R CD127 CXCR6 CD8+ T cells AA interferon gamma

TLDR ILC1-like cells may contribute to hair loss in alopecia areata.

The study examines the involvement of ILC1-like innate lymphocytes in alopecia areata (AA), identifying a novel population of NKG2D+ ILC1-like cells that secrete IFN-γ, contributing to hair follicle immune privilege loss and hair fiber dystrophy. Through rigorous phenotyping using markers such as CD49a, CD200R, CD127, and CXCR6, the authors differentiate these cells from NK cells, challenging the notion that AA is solely driven by CD8+ T cells. Despite limitations in ex vivo and in vivo models and budget constraints preventing single-cell RNA sequencing, the study provides insights into AA's molecular biology and proposes new therapeutic targets. Further research is suggested to refine the characterization of ILC1-like cells and explore their role in AA.

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