Updates in the Pathogenesis of Alopecia Areata

    April 2021 in “ Sohag Medical Journal ”
    Zeinab Abu Baha Gouda, Essam Nada, Hanan Assaf, Soha Aboeldahab
    Studysummary This review outlines the proposed theories behind the development of alopecia areata, emphasizing the autoimmune process involving lost immune privilege in hair follicles, and stresses the need to pinpoint specific pathogenic mechanisms for potential treatments.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 24

    1. Possible Role of ILC1 in the Pathogenesis of Alopecia Areata ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2019
    2. Vitamin D and Alopecia Areata: Possible Roles in Pathogenesis and Potential Implications for Therapy PubMed · 2019
    3. Alopecia Areata: Overview and Insights from January 2018 Journal of The American Academy of Dermatology · 2017
    4. Identification of Differentially Expressed miRNAs in Alopecia Areata That Target Immune-Regulatory Pathways Genes and immunity · 2017
    5. Changes of Serum Trace Elements Level in Patients with Alopecia Areata: A Meta-Analysis Journal of dermatology · 2017
    6. The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region and Hair Bulb Area in Chronic Alopecia Areata Patients Annals of dermatology/Annals of Dermatology · 2017
    7. Oxidative Damage Control in a Human Mini-Organ: Nrf2 Activation Protects Against Oxidative Stress-Induced Hair Growth Inhibition Journal of Investigative Dermatology · 2016
    8. CXCR3 Blockade Inhibits T Cell Migration Into the Skin and Prevents Development of Alopecia Areata Journal of Immunology · 2016
    9. Laser Capture Microdissection Reveals Transcriptional Abnormalities In Alopecia Areata Before, During, And After Active Hair Loss Journal of Investigative Dermatology · 2015
    10. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    11. Imbalance of T-Helper 17 and Regulatory T Cells in Patients with Alopecia Areata The Journal of Dermatology · 2015
    12. Translational Positioning of Janus Kinase (JAK) Inhibitors in Alopecia Areata EBioMedicine · 2015
    13. Association Between TLR1 Polymorphisms and Alopecia Areata Autoimmunity · 2014
    14. Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege Journal of Investigative Dermatology · 2013
    15. Oxidative Stress in Alopecia Areata: A Case-Control Study American Journal of Clinical Dermatology · 2013
    16. Somatostatin Expression in Human Hair Follicles and Its Potential Role in Immune Privilege ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2013
    17. Autoimmune Disease Induction in a Healthy Human Organ: A Humanized Mouse Model of Alopecia Areata Journal of Investigative Dermatology · 2012
    18. Abnormal Epigenetic Modifications in Peripheral Blood Mononuclear Cells from Patients with Alopecia Areata British Journal of Dermatology · 2011
    19. Transcriptional Profiling in Alopecia Areata Defines Immune and Cell Cycle Control Related Genes Within Disease-Specific Signatures Genomics · 2010
    20. Trichohyalin Is a Potential Major Autoantigen in Human Alopecia Areata Journal of Proteome Research · 2010
    21. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    22. Type 1 Interferon Signature in the Scalp Lesions of Alopecia Areata British Journal of Dermatology · 2010
    23. Alopecia Areata Update Journal of The American Academy of Dermatology · 2010
    24. Probing the Effects of Stress Mediators on the Human Hair Follicle American Journal of Pathology · 2007

    Related research 6

    1. Treatment With Oral Janus Kinase Inhibitors in Adult Patients With Alopecia Areata: A Systematic Review and Meta-Analysis Journal of the American Academy of Dermatology · 2023
    2. Oxidative Stress and Alopecia Areata Frontiers in medicine · 2023
    3. Understanding Immune Privilege in an Inducible Mouse Model of Primary Cicatricial Alopecia ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2023
    4. Familial Aggregation of Alopecia Areata Journal of the American Academy of Dermatology · 2016
    5. Inhibiting Janus Kinases to Treat Alopecia Areata Nature medicine · 2014
    6. The Immunopathobiology of Lichen Planopilaris [Thesis]. Manchester, UK: The University of Manchester; 2011. · 2011