Transcriptional Profiling in Alopecia Areata Defines Immune and Cell Cycle Control Related Genes Within Disease-Specific Signatures
September 2010
in “
Genomics
”
alopecia areata T-cell mediated immune response humoral mechanisms cellular proliferation arrest apoptotic dysregulation hair follicle structural proteins immune activation cell cycle disruption apoptosis-related mechanisms hair follicle cycling hair follicle regeneration RT-PCR microarray AA T-cell response immune response cell cycle arrest apoptosis hair follicle proteins immune system activation cell cycle issues hair growth cycle hair regrowth PCR gene array
Studysummary This study found distinct gene expression profiles in alopecia areata-affected skin, suggesting T-cell mediated immune responses and unique gene profiles between different stages of the disease.
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