Alopecia Areata: Gene Expression in Skin Samples from Patients

March 2001 in “ Clinics in dermatology ”

A.J.G. McDonagh, A.G. Messenger

Alopecia areata autoimmune T-cell mediated immune response humoral mechanism cellular proliferation arrest apoptotic dysregulation hair follicle structural proteins AA

Studysummary This study found that 363 genes were differentially expressed in alopecia areata skin compared to non-lesional skin, suggesting T-cell mediated immune responses and distinct gene profiles related to the disease's stage.

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research The Pathogenesis of Alopecia Areata

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This study found that a non-scarring alopecia in C3H/HeJ mice resembles human alopecia areata and may serve as a valuable model for studying specific subtypes of the human condition.

research IL-1 Alpha Inhibits Human Hair Follicle Growth And Hair Fiber Production In Whole-Organ Cultures

30 citations , August 1993 in “PubMed”

This study found that IL-1 alpha inhibits the growth of cultured human hair follicles and hair fibers, suggesting a potential role in inflammatory hair loss conditions like alopecia areata.

research Profile of Alopecia Areata: A Questionnaire Analysis of Patients and Families

161 citations , March 1992 in “International Journal of Dermatology”

This study analyzed survey responses from 800 alopecia areata patients and found a possible genetic association with increased insulin-dependent diabetes mellitus in relatives but not in the patients themselves.

research Failure of Passive Transfer of Serum From Patients With Alopecia Areata and Alopecia Universalis to Inhibit Hair Growth in Transplants of Human Scalp Skin Grafted Onto Nude Mice

60 citations , February 1992 in “British Journal of Dermatology”

In this study, serum from patients with alopecia areata or universalis did not affect hair growth in transplanted scalp skin grafts on nude mice, despite increased deposition of immunoreactants.

research Juvenile Versus Maturity-Onset Alopecia Areata: A Comparative Retrospective Clinical Study

164 citations , November 1989 in “Clinical and Experimental Dermatology”

This retrospective study found that juvenile alopecia areata is more severe and has a worse prognosis than maturity-onset alopecia areata.

research Critical Stages of Hair Development and Pigmentation in the Mouse

236 citations , January 1951 in “Physiological zoology”

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