Association Between TLR1 Polymorphisms and Alopecia Areata

    April 2014 in “ Autoimmunity ”
    Ho-Sik Seok, Dong Woo Suh, Byungchul Jo, Hwang-Bin Lee, Hyang Mi Jang, Hun Kuk Park, Bark‐Lynn Lew, Joo‐Ho Chung, Woo‐Young Sim
    TLDR A specific gene variant (rs4833095) is linked to a higher risk of alopecia areata in Koreans.
    The study investigated the association between TLR1 gene polymorphisms and alopecia areata (AA) in 239 AA patients and 248 controls. It found that the missense SNP rs4833095 was significantly associated with the development of AA, with various statistical models showing strong associations (e.g., codominant2, p = 0.002; recessive, p = 0.001). The promoter SNP rs5743557 showed a weaker association with AA development. Additionally, rs4833095 was weakly associated with the age of onset between 15 and 50 years. The findings suggested that rs4833095 of TLR1 might be linked to AA susceptibility in the Korean population.
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