The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region and Hair Bulb Area in Chronic Alopecia Areata Patients

    January 2017 in “ Annals of dermatology/Annals of Dermatology ”
    Jin Woo Hong, Chang Kyu Lee, Seung‐Min Ha … Kiho Kim
    Studysummary This study found that Th17 lymphocytes may play a more crucial role than cytotoxic T cells in the development of alopecia areata due to their infiltration around the hair bulb/bulge, which exacerbates hair loss as histopathological grade worsens.
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    Research cited in this study 6

    1. Stem Cells and Alopecia: A Review of Pathogenesis British Journal of Dermatology · 2012
    2. Renbök Phenomenon in a Patient with Alopecia Areata Universalis and Psoriasis The Journal of Dermatology · 2011
    3. Involvement of the Bulge Region with Decreased Expression of Hair Follicle Stem Cell Markers in Senile Female Cases of Alopecia Areata JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2010
    4. TGF-β2 Is Specifically Expressed in Human Dermal Papilla Cells and Modulates Hair Folliculogenesis Journal of Cellular and Molecular Medicine · 2009
    5. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001
    6. Transforming Growth Factor-β Receptor Type I and Type II Expression During Murine Hair Follicle Development and Cycling Journal of Investigative Dermatology · 1997

    Related research 2

    1. The Role of Lymphocytes in the Development and Treatment of Alopecia Areata Expert Review of Clinical Immunology · 2015
    2. Changes in Distribution Pattern of CD8 Lymphocytes in the Scalp in Alopecia Areata During Treatment With Diphenylcyclopropenone Archives of dermatological research · 2007