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Glossary Bulge Region

specific area in hair follicle housing stem cells

The bulge region is a specific area located in the outer root sheath of a hair follicle. It contains a reservoir of stem cells that are crucial for hair growth and regeneration. These stem cells can also contribute to the repair of the skin and other tissues, making the bulge region essential for both hair health and overall skin maintenance.

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Research

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The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region and Hair Bulb Area in Chronic Alopecia Areata Patients

research The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region as Well as the Hair Bulb Area in the Chronic Alopecia Areata Patients

18 citations , January 2017 in “Annals of dermatology/Annals of Dermatology”

This study found that Th17 lymphocytes may play a more crucial role than cytotoxic T cells in the development of alopecia areata due to their infiltration around the hair bulb/bulge, which exacerbates hair loss as histopathological grade worsens.

research Autofluorescence in the Stem Cell Region of the Hair Follicle Bulge

17 citations , March 2005 in “Journal of Investigative Dermatology”

This study found that human hair follicle bulge stem cells exhibited autofluorescence, potentially due to high flavin- and NAD-related compound levels, highlighting the need to consider this when using fluorescent antibodies for studying these cells.

research 083 More Expression of IL-17 than IFN-γ from CD49a-negative Tissue-Resident Memory T (Trm) cells at the Hair Bulge and Hair Bulb Region in the Scalp of Chronic Alopecia Areata Patients according to the Foxp3+mTregs depletion

September 2019 in “Journal of Investigative Dermatology”

This study found that in chronic alopecia areata, increased IL-17 expression and CD8+CD49a-Trm cell infiltration in hair follicles were associated with more severe histopathologic gradings, while Foxp3+mTreg infiltration decreased.

research Basal cell carcinoma possibly originates from the outer root sheath and/or the bulge region of the vellus hair follicle

107 citations , May 1999 in “Archives of Dermatological Research”

In this study, the immunohistochemical and lectin binding profiles of basal cell carcinoma closely resembled those of the outer root sheath of vellus hair follicles, suggesting a potential histochemical relationship.

Involvement of the Bulge Region with Decreased Expression of Hair Follicle Stem Cell Markers in Senile Female Cases of Alopecia Areata

research Involvement of the bulge region with decreased expression of hair follicle stem cell markers in senile female cases of alopecia areata

20 citations , December 2010 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

This study found that selective downregulation of CD200 in the bulge area might contribute to unusual bulge involvement in a subset of alopecia areata cases.

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Community Join

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community DHT Isn’t the Only Factor in Hair Loss and That Might Be the Key to a Real Cure

373 upvotes 6 months ago

Hair loss involves more than just DHT, with genetic factors like TRPS affecting hair follicles. Treatments such as Amplifica's AMP-601 and AMP-303 target stem cells for potential hair growth solutions.

community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community UVA researchers discovered stem cells that plays a crucial role in hair growth - We are closer than ever to the cure!

281 upvotes 1 year ago

Researchers at the University of Virginia discovered a new group of stem cells in hair follicles that could potentially restore hair growth. The findings suggest that activating these stem cells might offer a new way to combat hair loss, though practical treatments are still years away.

community Subcutaneous Scalp fat and Hair loss? Interested in others annecdotal experience or knowledge.

6 upvotes 3 years ago

Subcutaneous scalp fat may be linked to hair loss, with theories suggesting that fat loss can lead to reduced blood flow and increased DHT activity, contributing to hair loss. Treatments discussed include PRP/PRF injections and fat transfer to improve scalp thickness and blood flow.

community Neck tension, and hair loss, I am 100 percent sure that there is a connection

in Treatment 19 upvotes 2 years ago

The user believes neck tension and poor posture contribute to hair loss, noticing improvements with yoga and muscle relaxation. Replies suggest androgenic alopecia as the cause and recommend exercises.

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Learn

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learn Beta Polypeptide

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learn Hair Transplant

How long does it take for the donor area to heal after a hair transplant? The donor area typically heals within 5 to 14 days after a hair transplant.
What does the donor area look like after a hair transplant? The donor area may show slight redness and tiny scars but usually heals well and is often concealed by remaining hair.

learn Fluocinolone

Can long-term use of Fluocinolone affect the health of hair follicles? There is no long-term human trial measuring what topical fluocinolone does to hair follicles; what is documented is the label's warning about skin atrophy with prolonged use, plus a 2007 mouse study suggesting hair-follicle bulge stem cells do not repair steroid-induced atrophy.

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