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    Glossary Bulge Region

    specific area in hair follicle housing stem cells

    The bulge region is a specific area located in the outer root sheath of a hair follicle. It contains a reservoir of stem cells that are crucial for hair growth and regeneration. These stem cells can also contribute to the repair of the skin and other tissues, making the bulge region essential for both hair health and overall skin maintenance.

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    1. The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region as Well as the Hair Bulb Area in the Chronic Alopecia Areata Patients 2017 · 18 citations
    2. Autofluorescence in the Stem Cell Region of the Hair Follicle Bulge Journal of Investigative Dermatology · 2005 · 17 citations
    3. 083 More Expression of IL-17 than IFN-γ from CD49a-negative Tissue-Resident Memory T (Trm) cells at the Hair Bulge and Hair Bulb Region in the Scalp of Chronic Alopecia Areata Patients according to the Foxp3+mTregs depletion Journal of Investigative Dermatology · 2019
    4. Basal cell carcinoma possibly originates from the outer root sheath and/or the bulge region of the vellus hair follicle Archives of Dermatological Research · 1999 · 107 citations
    5. In vitro identification of a stem cell population from canine hair follicle bulge region 2017 · 5 citations
    6. Abstract 4300: Constitutive activation of Stat3 increases hair follicle progenitor population at the expense of bulge region keratinocyte stem cells Cancer Research · 2010
    7. Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen: heterogeneity and functional differences of various hair cycles Differentiation · 1994 · 130 citations
    8. Involvement of the bulge region with decreased expression of hair follicle stem cell markers in senile female cases of alopecia areata 2010 · 20 citations
    9. Human keratinocytes derived from the bulge region of hair follicles are refractory to differentiation International journal of oncology · 2009 · 8 citations
    10. The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z‐protein in cells of the bulge region 1999 · 5 citations
    11. The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z-protein in cells of the bulge region 1999 · 2 citations
    12. Isolation, Cultivation, and Morphological Characteristics of Hair Follicle Adult Stem Cells in the Bulge Region in Mouse and Human Microscopy research · 2020 · 1 citations
    13. Immune response involving the bulge region in addition to telogen conversion contributes to hair loss in a case of atypical drug-induced hypersensitivity syndrome The Journal of Dermatology · 2013 · 1 citations
    14. The Human Papillomavirus Type 11 Upstream Regulatory Region Triggers Hair-Follicle-Specific Gene Expression in Transgenic Mice Journal of Investigative Dermatology · 1999 · 9 citations
    15. Advances in the Study of Stem-Cell-Enriched Hair Follicle Bulge Cells: A Review Featuring Characterization and Isolation of Human Bulge Cells Dermatology · 2007 · 16 citations
    16. TR3 is preferentially expressed by bulge epithelial stem cells in human hair follicles Laboratory Investigation · 2016 · 7 citations
    17. The effects of gamma rays on the regeneration of hair follicles are carried over to later hair cycles International Journal of Radiation Biology · 2015 · 5 citations
    18. Effects of gamma rays on the regeneration of murine hair follicles in the natural hair cycle International Journal of Radiation Biology · 2017 · 3 citations
    19. Divergent proliferation patterns of distinct human hair follicle epithelial progenitor niches in situ and their differential responsiveness to prostaglandin D2 Scientific Reports · 2017 · 21 citations
    20. Histology and ultrastructure of canine hair follicle stem cells (cHFSCs) Journal of Entomology and Zoology Studies · 2020
    21. 503 A new chemosensory control of human hair growth: Olfactory receptor OR10J1 stimulation promotes scalp hair follicle growth and progenitor cell generation ex vivo Journal of Investigative Dermatology · 2024
    22. Hair Biology and Androgenetic Alopecia Advances in Cosmetic Surgery · 2018
    23. The G-Protein Couple Receptor Kinase 2 (GRK2) Orchestrates Hair Follicle Homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2024
    24. The Thinning Top: Why Old People Have Less Hair Journal of Investigative Dermatology · 2014 · 4 citations
    25. Conditional telomerase induction causes proliferation of hair follicle stem cells Nature · 2005 · 414 citations
    26. Thymosin β<sub>4</sub>increases hair growth by activation of hair follicle stem cells The FASEB Journal · 2003 · 98 citations
    27. Neural Potential of a Stem Cell Population in the Hair Follicle Cell Cycle · 2007 · 80 citations
    28. A Review: The Location, Molecular Characterisation and Multipotency of Hair Follicle Epidermal Stem Cells Annals of the Academy of Medicine Singapore · 2004 · 61 citations
    29. Hair follicles, their disorders and their opportunities Drug Discovery Today: Disease Mechanisms · 2008 · 48 citations
    30. Contrasting Localization of c-Myc with Other Myc Superfamily Transcription Factors in the Human Hair Follicle and During the Hair Growth Cycle 2001 · 45 citations