ILC1-Like Innate Lymphocytes in Human Autoimmunity: Lessons from Alopecia Areata

August 2021 in “ Journal of Investigative Dermatology ”

Rimma Laufer Britva, Aviad Keren, Marta Bertolini, R. Paus, Amos Gilhar

New to Alopecia Areata? There is a guide in the encyclopedia. Read the guide →

alopecia areata ILC1-like innate lymphocytes NKG2D hair follicles immune privilege autoimmunity SCID mice antigen-specific T cell AA immune privilege guardians

Studysummary This study found that ILC1-like cells can induce alopecia areata in healthy human hair follicles, suggesting that these cells might be a therapeutic target in AA management.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

View this study on jidonline.org →

Discuss this study in the Community →

Similar Research

5 / 1000+ results

research Author response: Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata

February 2023

This study found that innate lymphoid cells-type 1 (ILC1) can induce alopecia areata by disrupting hair follicle immune privilege without the involvement of classical CD8+ T cells.

research Decision letter: Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata

September 2022

This study found that innate lymphoid cells-type 1 (ILC1lc) can induce alopecia areata (AA) by disrupting hair follicle immune privilege and causing hair follicle dystrophy and regression in both ex vivo and in vivo settings.

research Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata

June 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study provides evidence that innate lymphoid cells-type 1 can induce alopecia areata in human hair follicles, challenging the view that it is solely a CD8+ T cell-driven autoimmune disease.

research Editor's evaluation: Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata

September 2022

This study found that ILC1-like cells can induce alopecia areata symptoms in both ex vivo human hair follicles and in vivo mouse models, challenging the view that alopecia areata is solely CD8+ T cell-driven.

research Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata

18 citations , February 2023 in “eLife”

This study indicates that innate lymphoid cells-type 1 may provoke alopecia areata by disrupting hair follicle immune privilege and inducing characteristic lesions, challenging the view that alopecia areata is purely an autoantigen-dependent, T cell-driven condition.