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GlossarySevere Combined Immunodeficient Mice (SCID mice)

laboratory mice with a genetic mutation causing a nonfunctional immune system

Severe Combined Immunodeficient (SCID) mice are laboratory mice that lack a functional immune system due to a genetic mutation. This makes them highly valuable in scientific research, particularly for studying human diseases, testing new drugs, and conducting cancer research, as they can accept human cells and tissues without rejecting them.

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research Mouse Models of Alopecia Areata: C3H/HeJ Mice Versus the Humanized AA Mouse Model

April 2019 in “Journal of Investigative Dermatology”

The humanized AA mouse model is better for testing new alopecia areata treatments.

research Use of Human Induced Pluripotent Stem Cell-Derived CD271+CD90+ Mesenchymal Stem Cells for the Generation of Hair Inductive Dermal Cells

September 2016 in “Journal of dermatological science”

Human induced pluripotent stem cells can be used to create cells that help grow hair.

research Human Wharton’s Jelly Mesenchymal Stem Cells Plasticity Augments Scar-Free Skin Wound Healing with Hair Growth

102 citations , April 2014 in “PloS one”

Wharton’s Jelly stem cells from the umbilical cord improve skin healing and hair growth without scarring.

research Autoimmunity: Alopecia Areata

143 citations , January 2004 in “Journal of Investigative Dermatology Symposium Proceedings”

Alopecia areata is an autoimmune disease causing hair loss, treatable with immune-modulating drugs, and linked to genetics.

Effect of Minoxidil Formulations on Human Scalp Skin Xenotransplants on SCID Mice: A Novel Pre-Clinical In Vivo Assay for Androgenetic Alopecia Research

research Effect of Minoxidil Formulations on Human Scalp Skin Xenotransplants on SCID Mice: A Novel Pre-Clinical In Vivo Assay for Androgenetic Alopecia Research

January 2022 in “Experimental Dermatology”

Minoxidil solution and foam both increase hair growth, but the solution works better than the foam.

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