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GlossarySevere Combined Immunodeficient Mice (SCID mice)

laboratory mice with a genetic mutation causing a nonfunctional immune system

Severe Combined Immunodeficient (SCID) mice are laboratory mice that lack a functional immune system due to a genetic mutation. This makes them highly valuable in scientific research, particularly for studying human diseases, testing new drugs, and conducting cancer research, as they can accept human cells and tissues without rejecting them.

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research Histologic Study of the Regeneration Process of Human Hair Follicles Grafted onto SCID Mice after Bulb Amputation

19 citations , November 2001 in “Journal of Investigative Dermatology Symposium Proceedings”

Human hair follicles can regenerate and recover after severe injury by going through a brief abnormal resting phase before growing again.

Effect of Minoxidil Formulations on Human Scalp Skin Xenotransplants on SCID Mice: A Novel Pre-Clinical In Vivo Assay for Androgenetic Alopecia Research

research Effect of Minoxidil Formulations on Human Scalp Skin Xenotransplants on SCID Mice: A Novel Pre-Clinical In Vivo Assay for Androgenetic Alopecia Research

January 2022 in “Experimental Dermatology”

Minoxidil solution and foam both increase hair growth, but the solution works better than the foam.

research New Topical Antiandrogenic Formulations Can Stimulate Hair Growth in Human Bald Scalp Grafted Onto Mice

37 citations , January 2000 in “International Journal of Pharmaceutics”

Topical treatments can regrow hair on bald scalps.

research Mouse Models of Alopecia Areata: C3H/HeJ Mice Versus the Humanized AA Mouse Model

April 2019 in “Journal of Investigative Dermatology”

The humanized AA mouse model is better for testing new alopecia areata treatments.

research Experimental Induction of Alopecia Areata-Like Hair Loss in C3H/HeJ Mice Using Full-Thickness Skin Grafts

131 citations , November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin grafts on mice can cause an immune response leading to hair loss, useful for studying human hair loss conditions.

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