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Glossary Autoimmunity

body's immune system attacks its own cells and tissues

Autoimmunity is a condition where the body's immune system mistakenly attacks its own cells and tissues, thinking they are foreign invaders. This can lead to various autoimmune diseases, such as rheumatoid arthritis or lupus, where the immune response causes inflammation and damage to specific organs or systems.

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Research

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research Autoimmunity: Alopecia Areata

143 citations , January 2004 in “Journal of Investigative Dermatology Symposium Proceedings”

This review discusses the autoimmune nature of alopecia areata, potential therapeutic targets, and highlights the need for further studies on immunomodulatory treatments and genetic factors, but it reports no new clinical results.

research The L412F variant of Toll-like receptor 3 (TLR3) is associated with cutaneous candidiasis, increased susceptibility to cytomegalovirus, and autoimmunity

55 citations , November 2010 in “Journal of Allergy and Clinical Immunology”

This study found that the TLR3 L412F genetic variant is associated with severe viral infections, especially CMV, and immune dysfunction in a subgroup of chronic mucocutaneous candidiasis patients.