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GlossaryImmunodeficient Mice

laboratory mice with weakened or absent immune systems

Immunodeficient mice, also known as immunocompromised mice, are laboratory mice that have a weakened or entirely absent immune system. This makes them valuable for scientific research, particularly in studying human diseases, cancer, and testing new treatments, as they can accept human cells and tissues without rejecting them.

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research Transplants from Balding and Hairy Androgenetic Alopecia Scalp Regrow Hair Comparably Well on Immunodeficient Mice

17 citations, May 2003 in “Journal of The American Academy of Dermatology”

Hair from balding and non-balding areas regrows similarly on mice.

research Experimental Induction of Alopecia Areata-Like Hair Loss in C3H/HeJ Mice Using Full-Thickness Skin Grafts

131 citations, November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin grafts on mice can cause an immune response leading to hair loss, useful for studying human hair loss conditions.

research Mice Engrafted with Human Fetal Thymic Tissue and Hematopoietic Stem Cells Develop Pathology Resembling Chronic Graft-Versus-Host Disease

47 citations, June 2013 in “Biology of blood and marrow transplantation”

Mice with human fetal thymic tissue and stem cells developed symptoms similar to chronic graft-versus-host disease.

research Human Induced Pluripotent Stem Cell-Derived Ectodermal Precursor Cells Contribute to Hair Follicle Morphogenesis In Vivo

64 citations, January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

Human stem cells can help form hair follicles in mice.

research Mouse Models for the Study of Human Hair Loss

36 citations, October 1996 in “Dermatologic Clinics”

Mice are useful for researching human hair loss and testing treatments, despite some differences between species.

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