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    Glossary Immunodeficient Mice

    laboratory mice with weakened or absent immune systems

    Immunodeficient mice, also known as immunocompromised mice, are laboratory mice that have a weakened or entirely absent immune system. This makes them valuable for scientific research, particularly in studying human diseases, cancer, and testing new treatments, as they can accept human cells and tissues without rejecting them.

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    1. Transplants from balding and hairy androgenetic alopecia scalp regrow hair comparably well on immunodeficient mice Journal of The American Academy of Dermatology · 2003 · 17 citations
    2. A novel hairless highly immunodeficient mice model optimized for in vivo imaging Laboratory Animal Research · 2026
    3. Histologic and Cell Kinetic Studies of Hair Loss and Subsequent Recovery Process of Human Scalp Hair Follicles Grafted onto Severe Combined Immunodeficient Mice Journal of Investigative Dermatology · 2000 · 31 citations
    4. A Spontaneous Deletion within the Desmoglein 3 Extracellular Domain of Mice Results in Hypomorphic Protein Expression, Immunodeficiency, and a Wasting Disease Phenotype ˜The œAmerican journal of pathology · 2014 · 11 citations
    5. Experimental Induction of Alopecia Areata-Like Hair Loss in C3H/HeJ Mice Using Full-Thickness Skin Grafts 1998 · 131 citations
    6. Follicles Twisted During Follicular Unit Excision Could Survive in the Skin of Nude Mice Dermatologic Surgery · 2025
    7. 080 Mouse models of alopecia areata: C3H/HeJ mice versus the humanized AA mouse model Journal of Investigative Dermatology · 2019
    8. Tissue engineering of human hair follicles using a biomimetic developmental approach Nature Communications · 2018 · 184 citations
    9. Human Induced Pluripotent Stem Cell–Derived Ectodermal Precursor Cells Contribute to Hair Follicle Morphogenesis In Vivo 2013 · 64 citations
    10. MOUSE MODELS FOR THE STUDY OF HUMAN HAIR LOSS Dermatologic Clinics · 1996 · 36 citations
    11. Cutaneous Retinoic Acid Levels Determine Hair Follicle Development and Downgrowth 2012 · 31 citations
    12. A New Humanized Mouse Model for Alopecia Areata Journal of Investigative Dermatology Symposium Proceedings · 2013 · 25 citations
    13. Sebaceous Gland Regeneration in Human Skin Xenografts Journal of Investigative Dermatology · 2010 · 9 citations
    14. Modeling Chemotherapy-Induced Hair Loss: From Experimental Propositions toward Clinical Reality 2016 · 6 citations
    15. Dissociated skin cells regenerate hair follicles in a microwound, “The Punch Assay” Experimental Dermatology · 2018 · 5 citations
    16. 3D multicellular micropatterning biomaterials for hair regeneration and vascularization Materials horizons · 2023 · 3 citations
    17. 937 Disruption of the innate lymphoid cell network alters the hair cycle during induced anagen 2023
    18. 1415 Induction of human hair growth using vascularized 3D hair follicle constructs 2018
    19. Faculty Opinions recommendation of Application of mesenchymal stem cells derived from bone marrow and umbilical cord in human hair multiplication. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2010
    20. Hair follicle regeneration from human pluripotent stem cells Journal of clinical & experimental dermatology research · 2017
    21. Histologic Study of the Regeneration Process of Human Hair Follicles Grafted onto SCID Mice after Bulb Amputation Journal of Investigative Dermatology Symposium Proceedings · 2001 · 19 citations
    22. Morphologic and Histologic Comparison of Hypertrophic Scar in Nude Mice, T-Cell Receptor, and Recombination Activating Gene Knockout Mice 2015 · 9 citations
    23. Mite Burden and Immunophenotypic Response to <i>Demodex musculi</i> in Swiss Webster, BALB/c, C57BL/6, and NSG Mice Comparative medicine · 2020
    24. Pseudo Pemphigus Phenotypes in Mice with Inactivated Desmoglein 3 ˜The œAmerican journal of pathology · 2015 · 5 citations
    25. Mice Engrafted with Human Fetal Thymic Tissue and Hematopoietic Stem Cells Develop Pathology Resembling Chronic Graft-versus-Host Disease Biology of blood and marrow transplantation · 2013 · 47 citations
    26. Patients with Compound Heterozygous Mutations in Forkhead Box N1 have a Severe Immunodeficiency while Maintaining Normal Skin and Hair Development 2017
    27. T Cell Immunodeficiency, Congenital Alopecia, and Nail Dystrophy 2022
    28. Research Highlights: γδ T cells regulate hair follicle neogenesis during adult wound healing Regenerative Medicine · 2013
    29. Reconstitution of full-thickness skin by microcolumn grafting Journal of Tissue Engineering and Regenerative Medicine · 2016 · 38 citations
    30. A model system to analyse the ability of human keratinocytes to form hair follicles Experimental Dermatology · 2014 · 15 citations