Mite Burden and Immunophenotypic Response to Demodex Musculi in Swiss Webster, BALB/c, C57BL/6, and NSG Mice

July 2020 in “ Comparative medicine ”

Mariya G Morris, Rodolfo J Ricart Arbona, Kathleen Daniels, Rui Gardner, Imaani Easthausen, W L Boteler, Gregory P Baseler, Gabrielle Pastenkos, Cheryl L. Perkins, Keith Henderson, Andrea Schietinger, Neil S Lipman

Demodex musculi alopecia topical treatment immunophenotypic response mite burden

TLDR NSG mice had the most mites, and genetic factors affect immune response and susceptibility.

The study investigated the mite burden and immunophenotypic response to *Demodex musculi* in Swiss Webster, BALB/c, C57BL/6, and NSG mice. It found that NSG mice had the highest mite burdens, while Swiss Webster and BALB/c mice showed higher mite loads compared to C57BL/6 mice. Immunophenotypic analysis revealed distinct immune responses among the strains, with genetic factors influencing susceptibility and immune reaction. Infested immunocompetent mice developed alopecia by day 112, and topical treatment effectively eradicated mites in BALB/c mice. The study highlighted the need for *D. musculi* surveillance in mouse colonies due to potential impacts on research outcomes.

View this study on europepmc.org →

Discuss this study in the Community →

Similar Research

5 / 249 results

research Proliferative and Non-Proliferative Lesions of the Rat and Mouse Integument

53 citations, January 2013 in “Journal of toxicologic pathology”

The project created a standardized system for classifying skin lesions in lab rats and mice.

research Mucocutaneous Side Effects of Antineoplastic Chemotherapy

55 citations, November 2004 in “Expert opinion on drug safety”

Chemotherapy often causes hair loss, nail changes, and mouth issues, but these are usually manageable.

Primary Scarring Alopecias: Review of Histopathological Findings of 37 Patients from the Department of Dermatology at the Hospital das Clínicas, Faculty of Medicine, University of São Paulo from 2000 to 2005

research Primary Scarring Alopecias: Review of Histopathological Findings of 37 Patients from the Department of Dermatology at the Hospital das Clínicas, Faculty of Medicine, University of São Paulo from 2000 to 2005

January 2011

Accurate diagnosis of cicatricial alopecias requires thorough scalp examination and multiple biopsy techniques.

research Notoedric Mange in Free-Ranging Masked Palm Civets (Paguma Larvata) in Japan

17 citations, December 2003 in “Veterinary dermatology”

Some masked palm civets in Japan have a skin disease caused by mites.

research Type 2 Innate Immunity Regulates Hair Follicle Homeostasis to Control Demodex Pathosymbionts

March 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

A specific immune response helps control mite populations on the skin, maintaining healthy hair follicles.

Mite Burden and Immunophenotypic Response to Demodex Musculi in Swiss Webster, BALB/c, C57BL/6, and NSG Mice

Related Community Posts Join

community Solving Hair Loss with Research at MIT

community Fixed redness & itching with tea tree oil shampoo. Hair also became thicker. Demodex may be the cause.

community Has anyone figure out how to deal with their itchy scalp when most ingredients aren't working?

community Vicious male pattern baldness TINGLING ITCH!