Evaluation of Animal Models Suitable for Hair Research and Regeneration

The document from 2018 evaluates various animal models for hair research and regeneration, emphasizing their importance due to the similarities in skin biology between humans and animals. It discusses the pathogenesis of hair loss, including genetic, hormonal, and immune factors, and the two FDA-approved treatments for androgenetic alopecia: Finasteride and Minoxidil. The document also explores gene therapy and the use of animal models, particularly mice, for studying hair growth and loss. Transgenic mice have been useful in modeling human diseases like androgenetic alopecia. The C57BL/6 and C3H/HeJ mouse strains are noted for their relevance in hair growth research. Additionally, rat models, such as the albino Wistar Bratislava rat and the Dundee Experimental Bald Rat, and other animals like rabbits and the Golden Syrian hamster, are discussed for their contributions to the field. The document acknowledges the limitations of animal models but concludes that they are essential for advancing the understanding and treatment of human hair diseases.