Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia in a C3H/HeJ Mouse Model

    February 2008 in “ ˜The œAmerican journal of pathology ”
    Motonobu Nakamura, Jun‐ichiro Jo, Yasuhiko Tabata, Osamu Ishikawa
    TLDR Controlled delivery of specific RNA and IL-4 restored hair growth in mice with autoimmune alopecia.
    The study demonstrated that controlled delivery of T-box21 (Tbx21) small interfering RNA (siRNA) significantly improved autoimmune alopecia (alopecia areata) in a C3H/HeJ mouse model. Using biodegradable cationized gelatin microspheres for siRNA delivery, the treatment effectively suppressed Tbx21 protein and MHC class II expression, leading to significant hair regrowth. Additionally, the study found that Th1 cytokine Ifng was highly expressed in alopecic skin and that its expression was suppressed by Il4 injections, which also reduced CD8 T cell infiltration and promoted hair regrowth. These findings suggested that targeting Tbx21 and modulating Th1/Th2 cytokine balance could be effective therapeutic strategies for alopecia areata. The study included 78 mice, with various treatment groups showing significant improvements in hair growth.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 1000+ results

      community Don’t like the density at all, 2nd hair transplant

      in Transplants  156 upvotes 2 weeks ago
      The user is unhappy with the results of their second hair transplant, feeling that grafts were wasted on an already transplanted hairline instead of increasing mid-scalp density. They regret stopping medications like Dutasteride, Minoxidil, and RU58841, which led to significant hair loss, and plan to restart them.

      community Can't figure out what I'm doing wrong

      in Treatment  3 upvotes 2 weeks ago
      A 38-year-old male experienced rapid hair loss progression and tried topical Minoxidil for 15 months without success, then switched to a combination spray with Minoxidil, Finasteride, and Tretinoin for two months, still seeing no improvement. Users suggest patience, as Finasteride can take six months to a year to show results, and recommend considering oral treatments if health permits, while also advising against washing off treatments too soon.

      community Don’t do like me. Don’t take a long break from Fin and Min

      in Chat  124 upvotes 3 months ago
      Stopping finasteride and minoxidil can cause significant hair shedding, so they should be continued indefinitely. Concerns about finasteride affecting fertility or causing birth defects are mostly unfounded, but some stop for personal reasons.

      community Don't think I can go on like this anymore

      in Chat  118 upvotes 3 months ago
      A 24-year-old is struggling with severe depression and anxiety due to hair loss, despite using dutasteride and oral minoxidil for two years. They are advised to consider shaving their head, exploring wigs or hair systems, and focusing on other aspects of life like health, relationships, and career.

      community Won’t pp405 and gt20029 be patented and be almost unreasonably expensive

      in Treatment  30 upvotes 5 months ago
      Concerns about the potential high cost of new hair loss treatments, pp405 and gt20029, were discussed, with some users willing to pay a premium if they are effective. Alternatives like finasteride and minoxidil are mentioned as current, more affordable options, and there is speculation about future generic versions and black market availability.

    Related Research

    4 / 4 results