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GlossaryMHC Class II

molecules on immune cells presenting antigens to T-helper cells

MHC Class II, or Major Histocompatibility Complex Class II, are molecules found on the surface of certain immune cells, such as dendritic cells, macrophages, and B cells. They play a crucial role in the immune system by presenting foreign antigens to T-helper cells, which then activate other immune responses to fight off infections.

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research Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche

220 citations, June 2013 in “The Journal of Pathology”

Lichen planopilaris may be an autoimmune disease causing hair loss due to immune system issues in hair follicles.

research Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia in a C3H/HeJ Mouse Model

69 citations, February 2008 in “The American journal of pathology”

Controlled delivery of specific RNA and IL-4 restored hair growth in mice with autoimmune alopecia.

research Calcitonin Gene-Related Peptide (CGRP) May Award Relative Protection from Interferon-γ-Induced Collapse of Human Hair Follicle Immune Privilege

47 citations, December 2011 in “Experimental Dermatology”

CGRP may help protect hair follicles from immune system attacks, potentially slowing hair loss.

research Self Prion Protein Peptides Are Immunogenic in Lewis Rats

14 citations, December 2001 in “Journal of autoimmunity”

Rats can develop an immune response to prion protein peptides, but it may cause severe skin issues in older rats.

research UVB-Induced Depletion of Donor-Derived Dendritic Cells Prevents Allograft Rejection of Immune-Privileged Hair Follicles in Humanized Mice

6 citations, November 2018 in “American journal of transplantation”

UV light helped human hair transplants survive in mice without broad immunosuppression.

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