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GlossaryMHC Class I Polypeptide-Related Sequence B

plays a role in immune response by signaling stressed cells

MHC Class I Polypeptide-Related Sequence B, also known as MICB, is a protein that plays a role in the immune system. It is part of the MHC (Major Histocompatibility Complex) class I family and is involved in the recognition and destruction of infected or cancerous cells by natural killer (NK) cells and certain T cells. This protein is important for the body's ability to detect and respond to cellular stress.

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research Alarmin Cytokines As Central Regulators Of Cutaneous Immunity

51 citations , March 2022 in “Frontiers in Immunology”

Alarmin cytokines are key in controlling skin immunity and inflammation.

research Perforin Expression by Cutaneous Gamma Delta T Cells

13 citations , August 2020 in “Frontiers in Immunology”

Gamma delta T cells in the skin help with healing and defense but can also cause autoimmune issues, and more research is needed to understand how they are activated.

research Dandruff Lesional Scalp Skin Exhibits Epidermal T Cell Infiltration and a Weakened Hair Follicle Immune Privilege

March 2024 in “International Journal of Cosmetic Science”

Dandruff is linked to increased T cells and weakened immune protection in hair follicles.

research Clinical Perspectives on the Age-Related Increase of Immunosuppressive Activity

55 citations , April 2022 in “Journal of Molecular Medicine”

Aging and chronic inflammation weaken the immune system, increasing cancer and infection risks.

research AIRE Deficiency Leads to the Development of Alopecia Areata-Like Lesions in Mice

2 citations , October 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

AIRE deficiency causes hair loss similar to alopecia areata in mice.

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