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GlossaryTh1 cytokines

signaling proteins produced by Type 1 helper T cells

Th1 cytokines are signaling proteins produced by a type of immune cell called Type 1 helper T cells (Th1 cells). These cytokines, such as interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α), play a crucial role in activating and directing other immune cells to fight off intracellular pathogens like viruses and certain bacteria. They are also involved in inflammatory responses, which can be relevant in conditions like autoimmune diseases and alopecia areata.

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research The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications

37 citations, December 2021 in “Cells”

Alopecia areata severity and treatment response are linked to specific cytokine levels.

research Alopecia Areata Profiling Shows TH1, TH2, and IL-23 Cytokine Activation Without Parallel TH17/TH22 Skewing

176 citations, August 2015 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

research Inheritance-Specific Dysregulation of Th1 and Th17-Associated Cytokines in Alopecia Areata

1 citations, August 2023 in “Biomolecules”

Certain immune-related proteins are higher in people with alopecia and their healthy relatives, hinting at a genetic link.

Case Report: Successful Treatment of Alopecia Universalis With Tofacitinib and Increased Cytokine Levels: Normal Therapeutic Reaction or Danger Signal?

research Case Report: Successful Treatment of Alopecia Universalis With Tofacitinib and Increased Cytokine Levels: Normal Therapeutic Reaction or Danger Signal?

June 2022 in “Frontiers in Immunology”

Tofacitinib regrew hair in a man with total hair loss but raised cytokine levels, needing more research on possible side effects.

research Anticytokine Therapy, Particularly Anti-IFN-γ, in Th1-Mediated Autoimmune Diseases

9 citations, May 2005 in “Expert Review of Clinical Immunology”

Blocking interferon-gamma might help treat various autoimmune diseases.

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community When someone posts a scalp tension theory

in Satire 265 upvotes 3 years ago

Hair loss theories discussed include poor blood flow, scalp tension, inflammation, and DHT. Treatments mentioned are massaging scalp, minoxidil, finasteride, and RU58841.