Cause of Androgenic Alopecia

    October 2013 in “ Plastic and reconstructive surgery. Global open ”
    Emin Tuncay Ustuner
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    TLDR Male pattern baldness may be caused by scalp pressure on hair follicles, which increases with age and leads to a cycle of hair loss. This process is not directly determined by genes.
    In 2013, Dr. Emin Tuncay Ustuner proposed a theory for the cause of Androgenic Alopecia (AGA), or male pattern baldness, suggesting that the pressure exerted on hair follicles by the weight of the scalp leads to hair loss. As individuals age, the thickness of the subcutaneous fat tissue and the volume of the dermis decrease, increasing the pressure on hair follicles. This pressure increase necessitates more androgen to stimulate hair growth, leading to an increase in 5-alpha reductase enzyme activity, which converts testosterone to Dihydrotestosterone (DHT). The increase in DHT then further erodes the subcutaneous fat tissue around the hair follicle, creating a cycle of hair loss. The document also noted that while genetic factors are involved in AGA, no specific gene has been identified, and the increase in DHT is not directly determined by genes.

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    2024 Official beginner guide for "I'm losing my hair, what can I do?"

    August 2024, 1 posts
    Henryk
    ...Finasteride is the absolute first line of defense to protecting your hair. Without it, you won't be able to target the root cause of your hair loss. DHT, which is a byproduct of testosterone, causes specific hair to miniaturize until the follicle is unable to produce any noticeable hair. Finasteri...

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