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    Glossary Severe Combined Immunodeficient Mice

    laboratory mice with a genetic mutation causing a nonfunctional immune system

    Severe Combined Immunodeficient (SCID) mice are laboratory mice that lack a functional immune system due to a genetic mutation. This makes them highly valuable in scientific research, particularly for studying human diseases, testing new drugs, and conducting cancer research, as they can accept human cells and tissues without rejecting them.

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    1. Histologic and Cell Kinetic Studies of Hair Loss and Subsequent Recovery Process of Human Scalp Hair Follicles Grafted onto Severe Combined Immunodeficient Mice Journal of Investigative Dermatology · 2000 · 31 citations
    2. 080 Mouse models of alopecia areata: C3H/HeJ mice versus the humanized AA mouse model Journal of Investigative Dermatology · 2019
    3. T Cell Immunodeficiency, Congenital Alopecia, and Nail Dystrophy 2022
    4. A New Humanized Mouse Model for Alopecia Areata Journal of Investigative Dermatology Symposium Proceedings · 2013 · 25 citations
    5. FOXN1 deficient nude severe combined immunodeficiency Orphanet journal of rare diseases · 2017 · 32 citations
    6. Expanding the Nude SCID/CID Phenotype Associated with FOXN1 Homozygous, Compound Heterozygous, or Heterozygous Mutations Journal of Clinical Immunology · 2021 · 30 citations
    7. Histologic Study of the Regeneration Process of Human Hair Follicles Grafted onto SCID Mice after Bulb Amputation Journal of Investigative Dermatology Symposium Proceedings · 2001 · 19 citations
    8. MOUSE MODELS FOR THE STUDY OF HUMAN HAIR LOSS Dermatologic Clinics · 1996 · 36 citations
    9. Human ClinicalPhenotype Associated with FOXN1 Mutations Advances in experimental medicine and biology · 2009 · 22 citations
    10. A novel hairless highly immunodeficient mice model optimized for in vivo imaging Laboratory Animal Research · 2026
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