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    Piroctone Olamine

    Piroctone olamine is an organic compound used as an antimicrobial active in anti-dandruff and anti-seborrhoeic dermatitis scalp products. It is the ethanolamine salt of piroctone, a hydroxamic acid derivative. It is described as a white to slightly yellowish-white crystalline powder with a mild characteristic odour, very slightly soluble in water and freely soluble in ethanol, chloroform, and ether. It has been marketed by Clariant under the trade name Octopirox.

    Information, not medical advice. Talk to a licensed doctor or pharmacist before starting or changing a treatment.

    Research 10

    1. Topical lotion beneficial in androgenetic alopecia Inpharma Weekly · 1996
    2. Clinical evaluation of the efficacy and safety of ‘ThriveCo anti-dandruff pre-shampoo treatment,’ containing ZenscalpinTM in the management of scalp dandruff in healthy adults Journal of Dermatology & Cosmetology · 2024
    3. Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations International Journal of Cosmetic Science · 2002 · 43 citations
    4. Antidandruff hair tonic containing piroctone olamine Cosmetics and toiletries · 1988 · 4 citations
    5. Scalp application of the antioxidant piroctone olamine reduces hair shedding in an 8‐week randomized, double‐blind, placebo‐controlled clinical study International journal of cosmetic science (Print) · 2021 · 1 citations
    6. 75202 Evaluation of the anti-dandruff and soothing effect of a hair conditioner containing 0.4% piroctone olamine and niacinamide Journal of the American Academy of Dermatology · 2026
    7. Improvement in the inflammatory aspect of androgenetic alopecia. A pilot study with an antimicrobial lotion Journal of Dermatological Treatment · 1996 · 40 citations
    8. Scalp application of antioxidants improves scalp condition and reduces hair shedding in a 24‐week randomized, double‐blind, placebo‐controlled clinical trial International Journal of Cosmetic Science · 2021 · 6 citations
    9. Clear scalp, clear mind: Examining the beneficial impact of dandruff reduction on physical, emotional and social wellbeing International Journal of Cosmetic Science · 2025 · 2 citations
    10. Highly Efficient Rinse-Off/Leave-On Scalp Care Treatments to Reduce Moderate to Severe Dandruff Journal of cosmetics, dermatological sciences and applications · 2013 · 2 citations
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    Community 10

    1. Minoxidl 5% and finasteride 1.25mg daily 11 months Reddit · 6 Aug 2025
    2. Anybody using piroctone olamine instead of ketoconazole shampoo? Reddit · 3 Aug 2026
    3. shampoo with piroctone olamine in US? Reddit · 14 Dec 2025
    4. Shoutout to Zinc pyrithione and Piroctone olamine Reddit · 27 Apr 2025
    5. Do any shampoos contain Piroctone Olamine in the US Reddit · 26 Dec 2024
    6. Piroctone olamine effective and better than ketoconazole? Reddit · 1 Oct 2024
    7. UK Shampoo recs - Piroctone Olamine Reddit · 25 Apr 2024
    8. piroctone olamine works better than nizoral? Reddit · 7 Nov 2019
    9. Follivera - Doctor recommended this as an minox alternative, does the ingredients make sense Reddit · 30 Mar 2026
    10. From almost 0 to ?: A journey through hair regrowth - big 4 Community · 2 Oct 2025
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