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Upadacitinib

also Rinvoq

JAK inhibitor sold as Rinvoq; approved in the EU for severe alopecia areata, under FDA review for it

Upadacitinib, sold under the brand name Rinvoq, is a medication used for the treatment of rheumatoid arthritis, psoriatic arthritis, atopic dermatitis, ulcerative colitis, Crohn's disease, ankylosing spondylitis, and axial spondyloarthritis. Upadacitinib is a Janus kinase (JAK) inhibitor that works by blocking the action of enzymes called Janus kinases. These enzymes are involved in setting up processes that lead to inflammation, and blocking their effect brings inflammation in the joints under control.

Information, not medical advice. Talk to a licensed doctor or pharmacist before starting or changing a treatment.

Research 10

  1. Effective treatment of alopecia universalis with oral upadacitinibJAAD Case Reports · 2022 · 17 citations
  2. Upadacitinib for the Management of Alopecia Totalis and Subtotalis in Pediatric Patients: A Case SeriesReports — Medical Cases Images and Videos · 2026 · 1 citation
  3. Upadacitinib for management of recalcitrant alopecia areata: A retrospective case seriesJAAD case reports · 2023 · 12 citations
  4. Upadacitinib for Alopecia Areata in Different Backgrounds: A Case SeriesClinical, cosmetic and investigational dermatology · 2024 · 8 citations
  5. Upadacitinib for Alopecia: Current Evidence and Clinical InsightsSkin Appendage Disorders · 2025 · 6 citations
  6. Long-term efficacy and safety of upadacitinib in the treatment of alopecia areata: A retrospective studyJournal of the American Academy of Dermatology · 2026
  7. Concomitant management of alopecia universalis and ulcerative colitis with upadacitinibInternal Medicine Journal · 2024 · 3 citations
  8. Alopecia Universalis in an Adolescent Successfully Treated with Upadacitinib—A Case Report and Review of the Literature on the Use of JAK Inhibitors in Pediatric Alopecia AreataDermatology and Therapy · 2023 · 35 citations
  9. Alopecia Areata – Effects of Treatment with Upadacitinib – Two Case ReportsClinical Cosmetic and Investigational Dermatology · 2026
  10. Management of comorbid Crohn’s disease and alopecia universalis with upadacitinib and oral minoxidilJournal of Dermatological Treatment · 2025 · 3 citations
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