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    CD8-Positive Lymphocytes in Graft-Versus-Host Disease of Humanized NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ Mice

    February 2015 in “ Journal of comparative pathology ”
    Steven T Laing, Stephen M. Griffey, Mary E. Moreno, Cheryl A. Stoddart
    Studysummary This study observed that NSG-hu-BLT mice developed graft-versus-host disease characterized by CD8+ T lymphocyte-related cell death in the skin and liver, which may affect their utility in other research areas.
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    Research cited in this study 1

    1. Mice Engrafted with Human Fetal Thymic Tissue and Hematopoietic Stem Cells Develop Pathology Resembling Chronic Graft-Versus-Host Disease Biology of blood and marrow transplantation · 2013