Off-Label Uses of Retinoids in Dermatology

The 2012 document discussed the off-label uses of retinoids, specifically isotretinoin and acitretin, in dermatology. Retinoids were found effective in treating various skin disorders, including severe acne, psoriasis, and keratinization disorders. They also showed promise in treating certain cancers and precancerous conditions. The document highlighted the use of retinoids in treating hair loss conditions, with a combination of 5% minoxidil and 0.01% tretinoin proving effective for male pattern hair loss. However, retinoids also had significant adverse effects, including teratogenic potential and hyperlipidemia. It was recommended that patients be maintained on the lowest effective retinoids dose to minimize these side effects. The document also emphasized the need for further research to standardize the dosage and treatment duration.