Evaluation of Clinical Adverse Effects and Laboratory Changes in Patients with Acne Vulgaris Treated with Oral Isotretinoin
June 2010
in “
Anais Brasileiros de Dermatologia
”
Studysummary This study found that isotretinoin is a safe and well-tolerated acne treatment, with common adverse effects like cheilitis manageable through symptomatic medication and no significant changes in lipid or liver enzyme levels.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study assessed the safety of oral isotretinoin in 150 patients with acne vulgaris, aged 15 to 32 years, by monitoring clinical adverse effects and laboratory changes before and during treatment. Cheilitis was the most frequent side effect, affecting 94% of patients, while systemic effects like headaches and hearing problems were rare. Laboratory tests showed minimal, non-significant changes in cholesterol, triglycerides, and liver enzymes. The study concluded that isotretinoin is a safe and well-tolerated medication for acne, with the benefits outweighing the risks, although it highlighted the need for careful monitoring of teratogenic risks and the use of contraception in female patients.
