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4 / 4 resultslearn Dutasteride
Heavy duty finasteride that comes with higher risks, but scalp injections seem safe and are gaining popularity
learn Cyproterone
a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor
learn GT20029
research compound made to degrade androgen receptors in scalp
Research
5 / 1000+ results![Pharmacological Mobilization of Endogenous Bone Marrow Stem Cells Promotes Liver Regeneration after Extensive Liver Resection in Rats](/images/research/f2115167-7c52-4a52-91e8-a4c5c05eda60/small/12731.jpg)
research Pharmacological Mobilization of Endogenous Bone Marrow Stem Cells Promotes Liver Regeneration after Extensive Liver Resection in Rats
Using a drug to activate bone marrow stem cells can help the liver regenerate and function better after major surgery in rats.
![Recent progress in the effect of ferroptosis of HSCs on the development of liver fibrosis](/images/research/4c6b0f4d-cb70-4614-b27a-bd6ff8d7ff9d/small/35713.jpg)
research Recent progress in the effect of ferroptosis of HSCs on the development of liver fibrosis
Inducing ferroptosis in hepatic stellate cells is crucial for treating liver fibrosis.
![Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure](/images/research/c1629e5b-3713-4c08-b295-d9fc97d0fda4/small/19627.jpg)
research Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure
Researchers created rat liver stem cells that could help repair liver failure in rats and may be useful for studying human liver diseases.
![AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells](/images/research/4c559e21-fc92-498a-a978-4bc05f194cc3/small/31828.jpg)
research AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells
AKR1D1 controls glucocorticoid levels and receptor activity in liver cells.
research Neural, adipocyte and hepatic differentiation potential of primary and secondary hair follicle stem cells isolated from Arbas Cashmere goats
Hair follicle stem cells from Arbas Cashmere goats can become fat, nerve, and liver cells.
Community Join
5 / 1000+ resultscommunity Progress: 3 months min 4 times a week/dermaroll twice a week/antigray shampoo
The post discusses hair regrowth progress after 3 months of using Minoxidil four times a week, dermarolling twice a week, and using an anti-gray shampoo. The conversation includes speculation about the effectiveness of the shampoo, with some users noting visible darkening and growth of hair.
community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp
Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.
community Mechanism of action of alfatradiol (17 alpha estradiol)
The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.
community FCE 28260: A Forgotten 5α-Reductase Inhibition
FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.
community I’m going balls to the wall with probably the most nuclear stack apart from hormone blockers, will update this thread monthly.
A user experimenting with an extreme hair loss treatment stack of Dutasteride, RU58841, 15 mg oral minoxidil, and microneedling, which sparked a debate among other users about the safety of this approach.