Modeling Chemotherapy-Induced Hair Loss: From Experimental Propositions Toward Clinical Reality

    February 2016 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Vladimir A. Botchkarev, Andrey A. Sharov
    Studysummary This study found that human scalp hair follicles transplanted onto chemotherapy-treated immunodeficient mice closely mimic chemotherapy-induced hair loss seen in cancer patients, providing a valuable model for research.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on jidonline.org →
    Discuss this study in the Community →

    Research cited in this study 8

    1. Complex Changes in the Apoptotic and Cell Differentiation Programs During Initiation of the Hair Follicle Response to Chemotherapy Journal of Investigative Dermatology · 2014
    2. Pathobiology of Chemotherapy-Induced Hair Loss The Lancet Oncology · 2013
    3. Chemotherapy-Induced Alopecia: Emotional Distress and Mitigation Strategies Seminars in Cutaneous Medicine and Surgery · 2009
    4. Prevention of Chemotherapy-Induced Alopecia in Rodent Models Cell stress & chaperones · 2008
    5. Dissecting the Impact of Chemotherapy on the Human Hair Follicle ˜The œAmerican journal of pathology · 2007
    6. A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice Journal of Investigative Dermatology · 2005
    7. Histologic and Cell Kinetic Studies of Hair Loss and Subsequent Recovery Process of Human Scalp Hair Follicles Grafted onto Severe Combined Immunodeficient Mice Journal of Investigative Dermatology · 2000
    8. Chemotherapy-Induced Alopecia in Mice: Induction by Cyclophosphamide, Inhibition by Cyclosporine A, and Modulation by Dexamethasone PubMed · 1994

    Related research 6

    1. Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil JAAD case reports · 2022
    2. Significant Relationship Between Temporal Hair Loss and Other Scalp Areas in Female Pattern Hair Loss Journal of Dermatology · 2020
    3. Protection Against Chemotherapy-Induced Alopecia: Targeting ATP-Binding Cassette Transporters in the Hair Follicle Trends in pharmacological sciences · 2013
    4. Pathobiology of Chemotherapy-Induced Hair Loss The Lancet Oncology · 2013
    5. The Changing Patterns of Hair Density and Thickness in South Korean Women with Hair Loss: Clinical Office-Based Phototrichogram Analysis International Journal of Dermatology · 2008
    6. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001