Modeling Chemotherapy-Induced Hair Loss: From Experimental Propositions Toward Clinical Reality

February 2016 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

Vladimir A. Botchkarev, Andrey A. Sharov

chemotherapy-induced hair loss human scalp hair follicles cyclophosphamide immunodeficient mice

Studysummary This study found that human scalp hair follicles transplanted onto chemotherapy-treated immunodeficient mice closely mimic chemotherapy-induced hair loss seen in cancer patients, providing a valuable model for research. Our plain-language summary of this paper — not a Tressless recommendation.

Yoon et al. developed an in vivo model for studying chemotherapy-induced hair loss by transplanting human scalp hair follicles onto chemotherapy-treated immunodeficient mice. Their findings showed that the response of these grafted hair follicles to cyclophosphamide closely resembled the hair loss observed in cancer patients undergoing chemotherapy. This model was considered more clinically relevant than previous models and was expected to be a valuable tool for understanding the mechanisms behind chemotherapy-induced hair loss.

View this study on jidonline.org →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

Complex Changes in the Apoptotic and Cell Differentiation Programs During Initiation of the Hair Follicle Response to Chemotherapy

research Complex Changes in the Apoptotic and Cell Differentiation Programs During Initiation of the Hair Follicle Response to Chemotherapy

12 citations , July 2014 in “Journal of Investigative Dermatology”

This study found that doxorubicin induces hair follicle apoptosis through TRAIL receptor signaling, providing insights for managing chemotherapy-induced hair loss.

research Pathobiology of Chemotherapy-Induced Hair Loss

218 citations , January 2013 in “The Lancet Oncology”

This review discusses the pathobiology of chemotherapy-induced alopecia and highlights challenges in managing it, reporting no new clinical results and emphasizing the need for well-designed preclinical models to develop effective treatments.

research Chemotherapy-Induced Alopecia: Emotional Distress and Mitigation Strategies

155 citations , March 2009 in “Seminars in Cutaneous Medicine and Surgery”

This review covers various strategies to manage chemotherapy-induced alopecia, highlighting that agents like AS101 and minoxidil can reduce its severity but not prevent it, with no new clinical results reported.

research Prevention of Chemotherapy-Induced Alopecia in Rodent Models

27 citations , March 2008 in “Cell stress & chaperones”

This study found that localized administration of heat or certain stress protein inducers effectively prevented chemotherapy-induced hair loss in rodent models without affecting chemotherapy efficacy.

research Dissecting the Impact of Chemotherapy on the Human Hair Follicle

99 citations , September 2007 in “The American journal of pathology”

This study found that organ-cultured human scalp hair follicles can mimic chemotherapy-induced damage in vivo and serve as a model to explore molecular targets and protective agents for hair follicle preservation.

research A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice

106 citations , June 2005 in “Journal of Investigative Dermatology”

This study defines classification criteria for hair follicle dystrophy using a mouse model of chemotherapy-induced alopecia, providing tools for standardized hair damage assessment.

research Histologic and Cell Kinetic Studies of Hair Loss and Subsequent Recovery Process of Human Scalp Hair Follicles Grafted onto Severe Combined Immunodeficient Mice

31 citations , August 2000 in “Journal of Investigative Dermatology”

This study found that when human hair follicles were grafted onto mice, they progressed through dystrophic stages and returned to normal growth, with stem cells aiding in recovery.

Chemotherapy-Induced Alopecia in Mice: Induction by Cyclophosphamide, Inhibition by Cyclosporine A, and Modulation by Dexamethasone

research Chemotherapy-Induced Alopecia in Mice: Induction by Cyclophosphamide, Inhibition by Cyclosporine A, and Modulation by Dexamethasone

36 citations , April 1994 in “PubMed”

This study introduces a mouse model of cyclophosphamide-induced alopecia, which effectively replicates human chemotherapy-induced hair loss and can be pharmacologically manipulated to study hair regrowth patterns.