Chemotherapy-Induced Alopecia: Emotional Distress and Mitigation Strategies

March 2009 in “ Seminars in Cutaneous Medicine and Surgery ”

Ralph M. Trüeb

chemotherapy-induced alopecia scalp cooling drug-specific antibodies hair growth cycle modifiers cytokines growth factors antioxidants inhibitors of apoptosis cell-cycle modifiers proliferation modifiers AS101 minoxidil CIA Rogaine

Studysummary This review covers various strategies to manage chemotherapy-induced alopecia, highlighting that agents like AS101 and minoxidil can reduce its severity but not prevent it, with no new clinical results reported.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Telogen Effluvium: Acute and Chronic Hair Loss Conditions

32 citations , October 2009 in “Dermatology”

This article describes acute and chronic telogen effluvium, highlighting the importance of differentiating them from androgenetic alopecia for accurate diagnosis and treatment strategies but includes no new clinical research findings.

research Chemotherapy-Induced Anagen Effluvium: Diffuse or Patterned?

28 citations , January 2007 in “Dermatology”

This article discusses the presentation of chemotherapy-induced anagen effluvium as either diffuse or patterned hair loss and reports no new clinical findings.

research Hair Loss Pattern Due to Chemotherapy-Induced Anagen Effluvium: A Cross-Sectional Observation

53 citations , January 2007 in “Dermatology”

This study suggests that chemotherapy-induced anagen effluvium represents patterned hair loss, with most patients retaining hairlines, but patterns do not vary significantly by age, symptoms, or chemotherapy type.

research Protection Against Chemotherapy-Induced Alopecia

97 citations , September 2006 in “Pharmaceutical Research”

This review discusses advances in protecting against chemotherapy-induced alopecia and reports no new clinical results; calcitriol and cyclosporine A emerged as promising agents in animal models with broader efficacy across multiple chemotherapy drugs.

research Optimal Management of Hair Loss (Alopecia) in Children

49 citations , January 2003 in “American Journal of Clinical Dermatology”

This review discusses various pediatric hair loss conditions and treatments, highlighting the importance of a holistic approach and noting that no single treatment is universally effective.

research Hair and Cancer Chemotherapy: Consequences and Nursing Care - A Literature Study

159 citations , September 2001 in “European Journal of Cancer Care”

This literature study reviews the consequences of hair loss due to chemotherapy and nursing care interventions but reports no new clinical results.

research Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors

153 citations , January 2001 in “Science”

In a neonatal rat model, this study found that topical CDK2 inhibitors reduced chemotherapy-induced hair loss in 33 to 50% of the animals, suggesting a potential strategy for preventing alopecia in cancer patients.

research Permanent Alopecia Following Chemotherapy and Bone Marrow Transplantation

63 citations , May 2000 in “Australasian Journal of Dermatology”

This case study reported a 23-year-old woman with chronic myeloid leukemia who developed permanent hair loss after chemotherapy and did not respond to topical minoxidil treatment.

research A Randomized Trial of Minoxidil in Chemotherapy-Induced Alopecia

127 citations , July 1996 in “Journal of The American Academy of Dermatology”

This study found that in women undergoing chemotherapy after breast surgery, topical minoxidil significantly shortened the duration of hair loss compared to a placebo without significant side effects.

research The Protective Role of the Immunomodulator AS101 Against Chemotherapy-Induced Alopecia: Studies on Human and Animal Models

85 citations , January 1996 in “International Journal of Cancer”

In this study, AS101 combined with chemotherapy significantly reduced the severity of chemotherapy-induced alopecia in non-small-cell-lung-cancer patients and may involve immune mechanisms related to IL-1 and PGE2.

research Minoxidil as a Prophylaxis of Doxorubicin-Induced Alopecia

49 citations , October 1994 in “Annals of Oncology”

Minoxidil not effective in preventing chemotherapy-induced hair loss.

research Reduced Linear Hair Growth Rates of Vellus and Terminal Hairs Produced by Human Balding Scalp Grafted onto Nude Mice

23 citations , December 1991 in “Annals of the New York Academy of Sciences”

This study reported that human balding scalp grafted onto nude mice showed reduced linear growth rates of both vellus and terminal hairs.

research Prevention of Doxorubicin-Induced Alopecia by Scalp Hypothermia: Relation to Degree of Cooling

53 citations , June 1982 in “The BMJ”

Cooling the scalp below 22°C before and during chemotherapy can help prevent hair loss.