Dissecting the Impact of Chemotherapy on the Human Hair Follicle

    September 2007 in “ ˜The œAmerican journal of pathology ”
    Enikő Bodó, Desmond J. Tobin, York Kamenisch, Tamás Bı́ró, Mark Berneburg, Wolfgang Funk, Ralf Paus
    TLDR Chemotherapy damages hair follicles, causing hair loss and other cellular changes.
    The document "Dissecting the Impact of Chemotherapy on the Human Hair Follicle" from October 2007 examined how chemotherapy, specifically 4-Hydroperoxycyclophosphamide (4-HC), affected human hair follicles (HFs) using an in vitro model. The study found that high concentrations of 4-HC significantly inhibited hair growth, induced premature catagen-like transformations, and caused HF damage through mechanisms such as reduced keratinocyte proliferation, increased apoptosis, DNA damage, and oxidative stress. The research highlighted the role of p53 and the potential protective effects of keratinocyte growth factor (KGF), which reduced apoptosis and increased keratinocyte proliferation. These findings provided insights into the complex mechanisms of chemotherapy-induced alopecia (CIA) and suggested potential strategies for mitigating hair loss in patients undergoing chemotherapy.
    Discuss this study in the Community →

    Research cited in this study

    20 / 20 results

    Related Community Posts Join

    6 / 33 results

      community 4 months update (fin + min + derma stamps)

      in Progress Pictures  644 upvotes 2 months ago
      The user shared a 4-month update on hair loss treatment using finasteride, minoxidil, and derma stamps, showing significant progress. The user experienced no side effects and plans to continue the treatment, updating monthly.

      community Let's talk about natural options and last resorts.

      in Chat  7 upvotes 7 months ago
      The user discusses their long struggle with hair loss, considering various treatments like hair transplants, hair systems, and natural methods such as micro-needling, vitamin supplements, and a healthy lifestyle. They express concerns about side effects from drugs like finasteride and ultimately lean towards using a hair system for better appearance and confidence.

      community Goodbye tressless. I’ve decided to give in to my hairloss.

      in Update  594 upvotes 1 year ago
      Kitchen_Plastic_2847 had been fighting hair loss since 2019-2020 and was initially successful in regrowing his hair with finasteride. However, after contracting Covid three times back to back at the start of 2021, he started to lose his hair again. He found a new dermatologist who prescribed him oral minoxidil along with finasteride, but eventually decided it wasn't worth spending all the money to try and save his hair.

    Similar Research

    5 / 1000+ results