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    Did you mean 4-Hydroxycyclophosphamide?
    Glossary 4-Hydroxycyclophosphamide

    active metabolite of cyclophosphamide used in chemotherapy

    4-Hydroxycyclophosphamide (4-HC) is an active metabolite of the chemotherapy drug cyclophosphamide. It is formed in the liver and is responsible for the drug's therapeutic effects, as well as some of its side effects. 4-HC works by interfering with the DNA of rapidly dividing cells, which makes it effective in treating certain cancers and autoimmune diseases.

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    1. Dissecting the Impact of Chemotherapy on the Human Hair Follicle ˜The œAmerican journal of pathology · 2007 · 99 citations
    2. Peroxisome proliferator-activated receptor-γ signalling protects hair follicle stem cells from chemotherapy-induced apoptosis and epithelial–mesenchymal transition 2021 · 19 citations
    3. Protective effect of Korean Red Ginseng against chemotherapeutic drug-induced premature catagen development assessed with human hair follicle organ culture model Journal of Ginseng Research · 2015 · 19 citations
    4. Modulation of Chemotherapy-Induced Human Hair Follicle Damage by 17-β Estradiol and Prednisolone: Potential Stimulators of Normal Hair Regrowth by “Dystrophic Catagen” Promotion? Journal of Investigative Dermatology · 2008 · 18 citations
    5. 1409 Temporary cell cycle arrest by ALRN-6924: A novel, p53-targeting strategy to protect human scalp hair follicles against cyclophosphamide-induced alopecia Journal of Investigative Dermatology · 2023
    6. Prevention and Treatment of Chemotherapy-Induced Alopecia: What Is Available and What Is Coming? Current Oncology · 2023 · 4 citations
    7. Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy Nature Communications · 2019 · 32 citations
    8. Present Chemotherapy Induced Alopecia and Research in Future Austin therapeutics · 2021
    9. Complex Changes in the Apoptotic and Cell Differentiation Programs during Initiation of the Hair Follicle Response to Chemotherapy Journal of Investigative Dermatology · 2014 · 12 citations
    10. Chemotherapy-Induced Alopecia InTech eBooks · 2012 · 2 citations
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