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Glossary 4-azasteroid

synthetic compound mimicking steroids with a nitrogen atom

A 4-azasteroid is a type of synthetic compound that mimics the structure of steroids but includes a nitrogen atom at the fourth position in its chemical structure. These compounds are often used in medical treatments to inhibit enzymes like 5-alpha-reductase, which can help manage conditions such as benign prostatic hyperplasia and androgenic alopecia (hair loss).

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Research

5 / 1000+ results

research Synthesis and 5α-Reductase Inhibitory Activity of C21 Steroids Having 1,4-diene or 4,6-diene 20-ones and 4-Azasteroid 20-Oximes

186 citations , December 2011 in “Molecules”

This study reported that while no synthesized compounds surpassed finasteride in 5α-reductase inhibitory activity, certain 4-azasteroid-2-oximes exhibited notable inhibition.

research 13C-NMR study of 4-azasteroids in solution and solid state

25 citations , June 2002 in “Steroids”

This study examined 4-azasteroids using 13C-NMR spectroscopy, detailing the NMR spectrum assignments and reporting a new molecular complex of finasteride with dioxane.

research Synthesis of a 4-azasteroid hormones compound

January 2009 in “Xiandai huagong”

This research outlines a chemical synthesis process for Finasteride, detailing the conversion of pregnadienolone acetate through various chemical reactions and modifications.

Effect of Solvent on Stereoselectivity in Pd/C (Type 39K)-Catalyzed Hydrogenation of Methyl 3-Oxo-4-Aza-5-Androstene-17-Carboxylate, a Key Intermediate for Finasteride and Dutasteride

research Effect of Solvent on Stereoselectivity in Pd/C (Type 39K)-Catalyzed Hydrogenation of Methyl 3-Oxo-4-aza-5-androstene-17-carboxylate, A Key Intermediate for Finasteride and Dutasteride

6 citations , July 2007 in “Organic Process Research & Development”

This study optimized the reaction conditions for the stereoselective hydrogenation of a compound used in manufacturing finasteride and dutasteride, improving the selectivity for the desired isomer.

research Azasteroids as inhibitors of testosterone 5α-reductase in mammalian skin

34 citations , February 1993 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

This study found that 4-MA is a potent inhibitor of testosterone 5α-reductase in human tissues, promising potential for treating androgen-dependent skin conditions like male pattern baldness.

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Community Join

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community Finasteride, dutasteride, and oral min- My experience

in Finasteride/Dutasteride 126 upvotes 5 years ago

User took Fin for 3 years, Dut for 7 months, and oral Min for 2 months without side effects. Fin stopped hair loss for 2 years, Dut maintained hair, and oral Min regrew thinning hair.

community 4 month hair growth update on 1mg Fin and 5mg liquid minoxidil along with HRT

203 upvotes 1 day ago

The user shared a 4-month hair growth update using 1mg finasteride, 5mg liquid minoxidil, and hormone replacement therapy (HRT), reporting significant hair regrowth. They also use a derma stamp, scalp massages, and a DHT-blocking shampoo.

community 4 months on 0.625 mg oral minoxidil & 1 year on 0.5 mg oral finasteride

6 upvotes 1 day ago

The user has been using 0.625 mg oral minoxidil for 4 months and 0.5 mg oral finasteride for a year to address hair thinning, with noticeable regrowth, especially after adding minoxidil. They experienced initial shedding and side effects like libido loss and facial/body hair thinning, and are considering adjusting their finasteride dosage due to side effects.

community 4 months on topical dutasteride and minoxidil

6 upvotes 1 day ago

The conversation is about a 29-year-old's 4-month progress using topical dutasteride and minoxidil for hair loss. Users inquire about the specific products, dosage, and any side effects.

community 4 months 0.5mg fin/ 1ml 5% minox 30 y/o

9 upvotes 2 days ago

A 30-year-old started using 0.5mg finasteride and 5% minoxidil once daily for hair loss, experiencing positive results with minimal side effects after 4 months. The user warns about minoxidil's toxicity to cats.

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Learn

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learn Finasteride

Frontline, gold standard treatment for combatting androgenic alopecia

learn Thymosin Beta 4

What is Thymosin Beta 4, and why is it being researched in relation to hair follicle function and regeneration? Thymosin Beta 4 is a peptide being researched for its potential to enhance hair follicle regeneration.
How is Thymosin Beta 4 typically incorporated into experimental or advanced hair growth products? Thymosin Beta 4 is not an ingredient in any approved or regulated hair-loss product — it is an unapproved research peptide (sold online as TB-500). Published hair studies are in rats and mice only, from one research group; there are no human trials, and the same literature reports it can promote tumour growth.
What role does Thymosin Beta 4 play in scalp biology compared to traditional hair loss treatments? Thymosin Beta 4 may enhance scalp biology but lacks extensive clinical validation compared to traditional treatments.
All 5 questions on Thymosin Beta 4 →

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