Synthesis of a 4-Azasteroid Hormones Compound

January 2009 in “ Xiandai huagong ”

Zang Hong-xia

4-azasteroid Finasteride Pregnadienolone acetate oxidation esterification ring closure dehydrogenation Propecia

TLDR Finasteride was successfully synthesized from Pregnadienolone acetate.

The document detailed a synthetic process for creating a 4-azasteroid hormone compound, specifically Finasteride. The synthesis involved multiple chemical reactions starting with Pregnadienolone acetate, which was transformed through a series of steps including oxidation, esterification, and ring closure. The final step involved dehydrogenation of the A-ring to produce Finasteride.

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Related Research

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research Synthesis of Finasteride

January 2007 in “The Journal of Pharmaceutical Practice”

The process to make finasteride is simple, cheap, and gives a good amount.