Synthesis of a 4-Azasteroid Hormones Compound

January 2009 in “ Xiandai huagong ”

Zang Hong-xia

4-azasteroid Finasteride Pregnadienolone acetate oxidation esterification ring closure dehydrogenation Propecia

TLDR Finasteride was successfully synthesized from Pregnadienolone acetate.

The document detailed a synthetic process for creating a 4-azasteroid hormone compound, specifically Finasteride. The synthesis involved multiple chemical reactions starting with Pregnadienolone acetate, which was transformed through a series of steps including oxidation, esterification, and ring closure. The final step involved dehydrogenation of the A-ring to produce Finasteride.

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community Finasteride, dutasteride, and oral min- My experience

in Finasteride/Dutasteride 126 upvotes 4 years ago

User took Fin for 3 years, Dut for 7 months, and oral Min for 2 months without side effects. Fin stopped hair loss for 2 years, Dut maintained hair, and oral Min regrew thinning hair.

community 4 month Dutasteride & topical Minoxidil [happy with progress]

in Progress Pictures 135 upvotes 3 days ago

The user is happy with the progress in hair density after using a regimen of oral Dutasteride, topical Minoxidil, Tretinoin cream, Ketoconazole shampoo, and an LLLT helmet. They reported no side effects and noted that Dutasteride and Tretinoin were particularly effective.

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in Progress Pictures 16 upvotes 2 weeks ago

The user is using oral minoxidil and finasteride for hair loss and plans to add topical minoxidil and a dermaroller. They also use ketoconazole shampoo to support hair regrowth.

community 4 Months of Dut (0.5mg) update

in Progress Pictures 181 upvotes 2 weeks ago

The conversation discusses using 0.5mg Dutasteride once a week for hair loss, with suggestions to increase frequency for better results. The user plans to reassess the need for a hair transplant in six months and is concerned about potential side effects like gynecomastia.

community 4 Months on Roman 3-in-1 (Topical) — Crown Progress? Switch to Oral or Dutasteride?

in Progress Pictures 3 upvotes 2 weeks ago

The user has been using Roman 3-in-1 topical treatment (finasteride 0.3%, minoxidil 6%, tretinoin 0.025%) and a 0.25 mm dermaroller for four months to address crown thinning. They are seeking advice on whether to continue with the current regimen, switch to oral finasteride, or try dutasteride for better results.

community 4.5 month of oral min+finasteride

in Progress Pictures 81 upvotes 3 weeks ago

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Related Research

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research Synthesis of Finasteride

January 2007 in “The Journal of Pharmaceutical Practice”

The process to make finasteride is simple, cheap, and gives a good amount.