Protective Effect of Korean Red Ginseng Against Chemotherapeutic Drug-Induced Premature Catagen Development Assessed With Human Hair Follicle Organ Culture Model

    July 2015 in “ Journal of Ginseng Research ”
    Dong In Keum, Long-Quan Pi, Sungjoo Hwang, Won Soo Lee
    Image of study
    TLDR Korean Red Ginseng may protect against hair loss caused by chemotherapy.
    The study explored the potential of Korean Red Ginseng (KRG) to protect against chemotherapy-induced alopecia (CIA) by using an in vitro human hair follicle organ culture model. The hair follicles were exposed to 4-hydroperoxycyclophosphamide (4-HC), which typically causes hair loss by harming hair matrix keratinocytes. The findings indicated that 4-HC not only inhibited hair growth and caused premature catagen phase but also led to increased apoptosis and altered expression of apoptosis-related proteins. KRG pretreatment was found to counteract these effects by maintaining hair growth, preventing premature catagen development, and normalizing protein expression levels. The study suggested that KRG could mitigate the effects of 4-HC on hair follicles by modulating apoptosis-related protein expression, potentially offering a protective effect against CIA. However, the document did not specify the number of hair follicles used in the study.
    Discuss this study in the Community →

    Research cited in this study

    15 / 15 results

    Related Community Posts Join

    6 / 200 results

      community Natural Remedies: Polyphenols and Hair Loss

       19 upvotes 5 years ago
      Natural remedies to treat hair loss, such as polyphenols, apple peel extract, grape seed extract, green tea extract, peppermint oil, pumpkin seed oil, apigenin, Ginkgo biloba, red clover extract, olive leaf extract, Ecklonia Cava and Grateloupia elliptica. In addition, terpenes, carotenoids, and tocopherols were discussed as potential treatments.

      community Study shows further evidence that finasteride and dutasteride take 12-18 months or more to show significant results. Do NOT give up early

      in Finasteride/Dutasteride  247 upvotes 1 year ago
      The conversation discusses the effectiveness of finasteride and dutasteride in treating hair loss, emphasizing that significant results often take 12-18 months or more. Dutasteride is generally considered superior, with similar or fewer side effects than finasteride, but patience is required for noticeable improvement.

      community This and ketoconazole 2% life changing

      in Ketoconazole  69 upvotes 1 year ago
      The post discusses the user's experience with hair loss treatment using finasteride, clobetasol propionate, and ketoconazole shampoo. The conversation warns about the potential side effects of clobetasol, a powerful topical steroid, and emphasizes its short-term usage.

      community Why Didn't the Pumkin Seed Oil Study Get More Attention?

      in Question  70 upvotes 5 years ago
      Pumpkin seed oil showed a 40% increase in hair count, but its effectiveness is questioned due to other ingredients in the supplement. Users discuss its potential compared to finasteride, with some expressing skepticism and others showing interest.

      community (Almost) 3 months on fin+min & microneedle.

      in Progress Pictures  1320 upvotes 1 year ago
      The user has been using 1mg finasteride every other day, 5% minoxidil daily, and microneedling every two weeks for three months to treat hair loss. They are happy with the progress and considering adding ketoconazole shampoo to their routine.

    Related Research

    6 / 6 results