Human Female Hair Follicles Are a Direct, Nonclassical Target for Thyroid-Stimulating Hormone

December 2008 in “ Journal of Investigative Dermatology ”

Enikő Bodó, Arno Kromminga, Tamás Bı́ró, István Borbíró, Erzsébet Gáspár, Michał A. Żmijewski, Nina van Beek, Lutz Langbein, Andrzej Słomiński, Ralf Paus

thyroid-stimulating hormone TSH hair follicles TSH receptors cAMP gene expression hair keratin keratin-associated proteins

Studysummary Thyroid-stimulating hormone affects hair follicles but doesn't change hair growth or color.

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The study investigated the role of thyroid-stimulating hormone (TSH) in human female hair follicles (HFs) and found that these follicles were direct, nonclassical targets for TSH. Despite the presence of TSH receptors (TSH-R) in the mesenchymal compartments of scalp HFs, TSH did not significantly affect hair growth, cycling, or pigmentation in vitro. However, TSH treatment increased cAMP secretion and altered gene expression, indicating functional TSH-R activity. The study involved approximately 30 HFs from two female donors and suggested that TSH might influence HF functions indirectly through mesenchymal signaling, affecting gene expression related to hair keratin and keratin-associated proteins. These findings highlighted the potential of HFs as a model for understanding nonclassical TSH functions beyond traditional thyroid-related activities.

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