Identification of Clustered Cells in Human Hair Follicle Responsible for MMP-9 Gelatinolytic Activity: Consequences for the Regulation of Hair Growth

June 2001 in “ International Journal of Dermatology ”

Françoise Jarrousse, S Boisnic, Marie‐Christine Branchet, Jean‐Yves Beranger, Gaston Godeau, Breton Lionel, Bruno Bernard, Yann F. Mahé

TLDR MMP-9 increase in hair follicles may lead to hair loss.

The study identified that human hair follicles in vitro primarily produced MMP-2 and MMP-9 gelatinolytic activities, with MMP-9 production significantly increasing after stimulation with EGF, TNF-α, or IL-1α. MMP-9 was localized in the lower part of the inner root sheath of anagen hair follicles. The findings suggested that the upregulation of MMP-9 by cytokines and EGF in the lower epithelial compartment of the hair bulb was a key mechanism contributing to hair follicle involution, which is observed in alopecia.

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