Protective Effect of Polysaccharide Derived from Natural Extract on Human Follicle Dermal Papilla Cell and Keratinocytes

    Jee Young Kim, Weon Jeong Bang, Young Hoon Joo, Sung Hyeon Lee, Chang Seok Lee
    TLDR Natural extracts like ginseng, green tea, shiitake, and aloe vera may help prevent hair loss by protecting hair-related cells.
    This study evaluated the skin-protective effects of polysaccharide extracts from ginseng, green tea, shiitake, and aloe vera on human follicle dermal papilla cells (HFDPC) and keratinocytes (HaCaT). The extracts were assessed for total sugar content and antioxidant activity. Results showed that these polysaccharides promoted cell proliferation and suppressed hydrogen peroxide-induced apoptosis in both cell types. The findings suggest that these natural extracts could be developed as effective ingredients for preventing hair loss in the cosmetics and pharmaceutical industries.
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