Comparison of Oral Minoxidil, Finasteride, and Dutasteride for Treating Androgenetic Alopecia

    Anik Gupta, Mesbah Uddin Talukder, G. Williams
    TLDR Dutasteride is the most effective for hair loss but may cause sexual and mental side effects.
    This document compares the efficacy and safety of oral minoxidil, finasteride, and dutasteride for treating androgenetic alopecia (AGA). Dutasteride (0.5 mg/d) is considered the most effective, followed by finasteride (5 mg/d), minoxidil (5 mg/d), finasteride (1 mg/d), and minoxidil (0.25 mg/d). Oral minoxidil can cause hypertrichosis and cardiovascular symptoms, while finasteride and dutasteride are linked to sexual dysfunction and neuropsychiatric side effects. Dutasteride, with a longer half-life of about 5 weeks, inhibits both type I and II 5α-reductase, reducing DHT levels more effectively than finasteride, which only inhibits type II.
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