LINCS Dataset-Based Repositioning of Dutasteride as an Anti-Neuroinflammation Agent

    October 2021 in “ Brain Sciences ”
    Dan Luo, Lu Han, Shengqiao Gao … Wenxia Zhou
    Studysummary This study reported that dutasteride, identified through a drug repurposing strategy, showed the potential to reduce neuroinflammation and cognitive impairment in LPS-stimulated models.
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    Research cited in this study 9

    1. Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm The World Journal of Men's Health · 2020
    2. Repeated Finasteride Administration Induces Depression-Like Behavior in Adult Male Rats Behavioural Brain Research · 2019
    3. Treatment of Male Rats with Finasteride, an Inhibitor of 5alpha-Reductase Enzyme, Induces Long-Lasting Effects on Depressive-Like Behavior, Hippocampal Neurogenesis, Neuroinflammation, and Gut Microbiota Composition Psychoneuroendocrinology · 2018
    4. The 5α-Reductase Inhibitor Finasteride Exerts Neuroprotection Against Ischemic Brain Injury in Aged Male Rats Translational Stroke Research · 2018
    5. Effect of the 5α-Reductase Enzyme Inhibitor Dutasteride in the Brain of Intact and Parkinsonian Mice Journal of steroid biochemistry and molecular biology/˜The œJournal of steroid biochemistry and molecular biology · 2017
    6. Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome Skin appendage disorders · 2016
    7. The 5α-Reductase Inhibitor Dutasteride but Not Finasteride Protects Dopamine Neurons in the MPTP Mouse Model of Parkinson’s Disease Neuropharmacology · 2015
    8. Dutasteride for the Treatment of Benign Prostatic Hyperplasia Expert opinion on pharmacotherapy · 2013
    9. The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride Journal of The American Academy of Dermatology · 2006