Analytical Methods of Dutasteride: An Overview

December 2023 in “ Annals of phytomedicine ”

M. Sumithra, P. Shanmugasundaram, S. Dheepika

dutasteride RP-HPLC liquid chromatography-mass spectrometry 5-alpha-reductase inhibitor androgenetic alopecia finasteride Avodart reverse-phase high-performance liquid chromatography LC-MS Propecia

TLDR Dutasteride is more effective than finasteride for hair loss treatment.

The review article discusses various analytical methods for determining the dosage of dutasteride, focusing on RP-HPLC techniques for its detection in bulk and pharmaceutical formulations. It highlights the development of a sensitive liquid chromatography-mass spectrometry method for measuring dutasteride and its metabolites in human plasma. The methods are noted for their precision, accuracy, cost-effectiveness, and compliance with validation requirements, making them suitable for routine analysis. Dutasteride, a potent 5-alpha-reductase inhibitor, is suggested to be more effective than finasteride in treating androgenetic alopecia due to its higher potency in inhibiting both type-1 and type-2 isoenzymes.

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58 citations, March 2006 in “Current topics in medicinal chemistry”

Dutasteride effectively treats benign prostatic hyperplasia and may reduce prostate cancer risk.