Analytical Methods of Dutasteride: An Overview

The review article discusses various analytical methods for determining the dosage of dutasteride, focusing on RP-HPLC techniques for its detection in bulk and pharmaceutical formulations. It highlights the development of a sensitive liquid chromatography-mass spectrometry method for measuring dutasteride and its metabolites in human plasma. The methods are noted for their precision, accuracy, cost-effectiveness, and compliance with validation requirements, making them suitable for routine analysis. Dutasteride, a potent 5-alpha-reductase inhibitor, is suggested to be more effective than finasteride in treating androgenetic alopecia due to its higher potency in inhibiting both type-1 and type-2 isoenzymes.