Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

    Bu Young Choi
    Studysummary This review discusses the role of Wnt/β-catenin signaling in hair follicle regeneration and highlights recent progress in developing hair loss treatments targeting this pathway, but reports no new clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 48

    1. Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy International Journal of Molecular Sciences · 2020
    2. Study on the Chemical Constituents of Nut Oil from Prunus Mira Koehne and the Mechanism of Promoting Hair Growth Journal of ethnopharmacology · 2020
    3. Macrophage-Derived Extracellular Vesicle Promotes Hair Growth Cells · 2020
    4. Monoterpenoid Loliolide Regulates Hair Follicle Inductivity of Human Dermal Papilla Cells by Activating the Akt/β-Catenin Signaling Pathway Journal of Microbiology and Biotechnology · 2019
    5. Ginkgolide B and Bilobalide Promote Growth and Increase β-Catenin Expression in Hair Follicle Dermal Papilla Cells of American Minks BioFactors · 2019
    6. In Silico Analysis of Gene Expression Data from Bald Frontal and Haired Occipital Scalp to Identify Candidate Genes in Male Androgenetic Alopecia Archives of Dermatological Research · 2019
    7. Beta-Catenin-Mediated Hair Growth Induction Effect of 3,4,5-Tri-O-Caffeoylquinic Acid Aging · 2019
    8. Costunolide: A Bioactive Sesquiterpene Lactone with Diverse Therapeutic Potential International Journal of Molecular Sciences · 2019
    9. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    10. Flavonoid Silibinin Increases Hair-Inductive Property Via Akt and Wnt/β-Catenin Signaling Activation in 3-Dimensional Spheroid Cultured Human Dermal Papilla Cells Journal of Microbiology and Biotechnology · 2019
    11. The Balance of BMP6 and WNT10B Regulates the Telogen-Anagen Transition of Hair Follicles Cell Communication and Signaling · 2019
    12. Dickkopf-1 Expression in Androgenetic Alopecia and Alopecia Areata in Male Patients American Journal of Dermatopathology · 2019
    13. Morroniside Regulates Hair Growth and Cycle Transition via Activation of the Wnt/β-Catenin Signaling Pathway Scientific Reports · 2018
    14. Costunolide Promotes the Proliferation of Human Hair Follicle Dermal Papilla Cells and Induces Hair Growth in C57BL/6 Mice Journal of Cosmetic Dermatology · 2018
    15. Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy Cancer Research · 2017
    16. Hair Regenerative Mechanisms of Red Ginseng Oil and Its Major Components in the Testosterone-Induced Delay of Anagen Entry in C57BL/6 Mice Molecules · 2017
    17. Epidermal E-Cadherin Dependent β-Catenin Pathway Is Phytochemical Inducible and Accelerates Anagen Hair Cycling Molecular therapy · 2017
    18. Effect of Sinapic Acid on Hair Growth Promotion in Human Hair Follicle Dermal Papilla Cells via Akt Activation Archives of Dermatological Research · 2017
    19. Rice Bran Mineral Extract Increases the Expression of Anagen-Related Molecules in Human Dermal Papilla Through Wnt/Catenin Pathway Food & Nutrition Research · 2017
    20. 3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling Biomolecules & Therapeutics · 2016
    21. Activating Beta-Catenin Signaling in CD133-Positive Dermal Papilla Cells Increases Hair Inductivity FEBS Journal · 2016
    22. STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction Journal of Investigative Dermatology · 2016
    23. Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/β-Catenin Signaling Cellular physiology and biochemistry · 2016
    24. Malva Verticillata Seed Extracts Upregulate the Wnt Pathway in Human Dermal Papilla Cells International Journal of Cosmetic Science · 2015
    25. Hair Growth Promotion Activity and Its Mechanism of Polygonum Multiflorum Evidence-based Complementary and Alternative Medicine · 2015
    26. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    27. Treatment of MSCs with Wnt1a-Conditioned Medium Activates DP Cells and Promotes Hair Follicle Regrowth Scientific Reports · 2014
    28. CCN2 Modulates Hair Follicle Cycling in Mice Molecular Biology of the Cell · 2013
    29. Hair Growth-Promoting Activity of Hot Water Extract of Thuja Orientalis BMC Complementary and Alternative Medicine · 2013
    30. Adenovirus-Mediated Wnt5a Expression Inhibits the Telogen-To-Anagen Transition of Hair Follicles in Mice International journal of medical sciences · 2013
    31. Hair Growth-Promoting Effect of Aconiti Ciliare Tuber Extract Mediated by the Activation of Wnt/β-Catenin Signaling Life Sciences · 2012
    32. Adenovirus-Mediated Wnt10b Overexpression Induces Hair Follicle Regeneration Journal of Investigative Dermatology · 2012
    33. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration Journal of Investigative Dermatology · 2012
    34. Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation Development · 2012
    35. Reprogramming Adult Dermis to a Neonatal State Through Epidermal Activation of Beta-Catenin Development · 2011
    36. Topical Application of Polygonum Multiflorum Extract Induces Hair Growth of Resting Hair Follicles Through Upregulating Shh and β-Catenin Expression in C57BL/6 Mice Journal of Ethnopharmacology · 2011
    37. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    38. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    39. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    40. Keratinocyte Growth Inhibition Through the Modification of Wnt Signaling by Androgen in Balding Dermal Papilla Cells ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2009
    41. Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion Stem Cells · 2006
    42. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    43. In Vivo and In Vitro Evaluation of Hair Growth Potential of Hibiscus Rosa-Sinensis Linn. Journal of Ethnopharmacology · 2003
    44. Promotion of Hair Growth by Ginseng Radix on Cultured Mouse Vibrissal Hair Follicles Phytotherapy Research · 2003
    45. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    46. Treatment of Hair Loss The New England Journal of Medicine · 1999
    47. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    48. Finasteride The New England Journal of Medicine · 1994

    Related research 6

    1. What Can Complex Dietary Supplements Do for Hair Loss and How Can It Be Validly Measured: A Review Applied Sciences · 2020
    2. Blockade of S100A3 Activity Inhibits Murine Hair Growth Genetics and Molecular Research · 2015
    3. Electron Paramagnetic Resonance Spectroscopy for Investigating Murine Telogen Skin After Spontaneous or Depilation-Induced Hair Growth Journal of Dermatological Science · 2008
    4. Alopecia Journal of the Korean Medical Association · 2002
    5. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001
    6. Treatment of Hair Loss The New England Journal of Medicine · 1999