Rice Bran Mineral Extract Increases the Expression of Anagen-Related Molecules in Human Dermal Papilla Through Wnt/Catenin Pathway

The 2017 study explored the impact of rice bran mineral extract (RBM) on human dermal papilla cells (DPCs) and its potential to promote hair growth by activating the Wnt/β-catenin signaling pathway. The results showed that RBM treatment led to a significant increase in the expression of anagen-related molecules such as type I collagen, fibronectin, alkaline phosphatase (ALP), β-catenin, and Wnt-3a, while decreasing the expression of the inflammatory marker IL-1α. These changes suggest that RBM could prolong the anagen phase of hair growth and potentially prevent hair loss. The study also found that RBM did not cause apoptosis in DPCs, indicating its safety for use in cosmetic products. The study concluded that RBM has the potential to restore DPC activity and decrease inflammatory-related markers, which could make it a beneficial ingredient in hair growth and hair loss prevention products. The number of participants or cells used in the study was not specified in the summary.